Thomas Fletcher Tedder, PhD

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Professor of Immunology
Department:
Immunology
Address:
353 Jones Building, 207 Resear
Box 3010 DUMC
Durham, NC 27710
Office Telephone:
(919) 684-3681
Training:
  • PhD, University of Alabama at Birmingham, 1984
Research Interests:
Area of Study: Structure and function of B lymphocyte cell surface molecules that regulate B cell function, activation and signal transduction.

Overview: The focus of our laboratory is the identification, structural characterization, and functional analysis of cell surface molecules that regulate B lymphocyte development and function. Cell surface molecules allow B cells to communicate with the extracellular environment by serving as transmembrane regulators, receptors for soluble factors, or by mediating cell–cell interactions. Our studies of B-cell–associated cell surface receptors, including CD19, CD20, CD21, CD22 and CD83, are aimed at determining how these molecules function, what their ligands are, how they generate transmembrane signals and regulate B cell development, survival and activation. The role of CD83 in dendritic and B cell biology is also being examined. These studies lay the foundation for investigating mechanisms of immune dysregulation and the pathogenesis of immune disorders, such as autoimmunity, neoplastic transformation, and immunodeficiency syndromes. We have expertise in cellular immunology, biochemistry, and molecular biology and are applying a wide range of techniques in determining the function of these molecules. Many of these studies depend on the use of transgenic mice which overexpress these regulatory molecules or the generation and analysis of knockout mice lacking these receptors. Current studies are focused on identifying the molecular and cellular mechanisms by which B cells regulate T cell function and autoimmunity, with a particular emphasis on a regulatory B cell subset we identified that controls immune and inflammatory responses. Current studies also focus on identifying the molecular and cellular mechanisms by which CD19, CD20 and CD22 mAb immunotherapies are effective for treating B cell malignancies and autoimmunity. There are currently 20 investigators within the laboratory, including myself, two Assistant Professor’s, ten postdoctoral and clinical fellows, one graduate student, a laboratory Manager, two technicians, and three undergraduate students.
Representative Publications:
  • DiLillo, DJ; Griffiths, R; Seshan, SV; Magro, CM; Ruiz, P; Coffman, TM; Tedder, TF. B lymphocytes differentially influence acute and chronic allograft rejection in mice. Journal of immunology (Baltimore, Md. : 1950). 2011;186:2643-2654.  Abstract
  • DiLillo, DJ; Horikawa, M; Tedder, TF. B-lymphocyte effector functions in health and disease. Immunologic Research. 2011;49:281-292.  Abstract
  • Iwata, Y; Matsushita, T; Horikawa, M; Dilillo, DJ; Yanaba, K; Venturi, GM; Szabolcs, PM; Bernstein, SH; Magro, CM; Williams, AD; Hall, RP; St Clair, EW; Tedder, TF. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood. 2011;117:530-541.  Abstract
  • Kohrt, HE; Houot, R; Goldstein, MJ; Weiskopf, K; Alizadeh, AA; Brody, J; Müller, A; Pachynski, R; Czerwinski, D; Coutre, S; Chao, MP; Chen, L; Tedder, TF; Levy, R. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood. 2011;117:2423-2432.  Abstract
  • Matsushita, T; Tedder, TF. Identifying regulatory B cells (B10 cells) that produce IL-10 in mice. Methods in molecular biology (Clifton, N.J.). 2011;677:99-111.  Abstract
  • Pellegrini, M; Calzascia, T; Toe, JG; Preston, SP; Lin, AE; Elford, AR; Shahinian, A; Lang, PA; Lang, KS; Morre, M; Assouline, B; Lahl, K; Sparwasser, T; Tedder, TF; Paik, JH; DePinho, RA; Basta, S; Ohashi, PS; Mak, TW. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 2011;144:601-613.  Abstract
  • Poe, JC; Smith, SH; Haas, KM; Yanaba, K; Tsubata, T; Matsushita, T; Tedder, TF. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PloS one. 2011;6:e22464.  Abstract
  • Winer, DA; Winer, S; Shen, L; Wadia, PP; Yantha, J; Paltser, G; Tsui, H; Wu, P; Davidson, MG; Alonso, MN; Leong, HX; Glassford, A; Caimol, M; Kenkel, JA; Tedder, TF; McLaughlin, T; Miklos, DB; Dosch, HM; Engleman, EG. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nature Medicine. 2011;17:610-617.  Abstract
  • Yanaba, K; Yoshizaki, A; Asano, Y; Kadono, T; Tedder, TF; Sato, S. IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model. The American journal of pathology. 2011;178:735-743.  Abstract
  • Ait-Oufella, H; Herbin, O; Bouaziz, JD; Binder, CJ; Uyttenhove, C; Laurans, L; Taleb, S; Van Vré, E; Esposito, B; Vilar, J; Sirvent, J; Van Snick, J; Tedgui, A; Tedder, TF; Mallat, Z. B cell depletion reduces the development of atherosclerosis in mice. The Journal of Experimental Medicine. 2010;207:1579-1587.  Abstract
  • Carlson, MJ; Fulton, LM; Coghill, JM; West, ML; Burgents, JE; Wan, Y; Panoskaltsis-Mortari, A; Tedder, TF; Blazar, BR; Serody, JS. L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation. American Journal of Transplantation. 2010;10:2596-2603.  Abstract
  • DiLillo, DJ; Matsushita, T; Tedder, TF. B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Annals of the New York Academy of Sciences. 2010;1183:38-57.  Abstract
  • DiLillo, DJ; Yanaba, K; Tedder, TF. B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. Journal of immunology (Baltimore, Md. : 1950). 2010;184:4006-4016.  Abstract
  • Haas, KM; Watanabe, R; Matsushita, T; Nakashima, H; Ishiura, N; Okochi, H; Fujimoto, M; Tedder, TF. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. Journal of immunology (Baltimore, Md. : 1950). 2010;184:4789-4800.  Abstract
  • Herbst, R; Wang, Y; Gallagher, S; Mittereder, N; Kuta, E; Damschroder, M; Woods, R; Rowe, DC; Cheng, L; Cook, K; Evans, K; Sims, GP; Pfarr, DS; Bowen, MA; Dall'Acqua, W; Shlomchik, M; Tedder, TF; Kiener, P; Jallal, B; Wu, H; Coyle, AJ. B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody. The Journal of pharmacology and experimental therapeutics. 2010;335:213-222.  Abstract
  • Ishiura, N; Nakashima, H; Watanabe, R; Kuwano, Y; Adachi, T; Takahashi, Y; Tsubata, T; Okochi, H; Tamaki, K; Tedder, TF; Fujimoto, M. Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. European Journal of Immunology. 2010;40:1192-1204.  Abstract
  • Kuijpers, TW; Bende, RJ; Baars, PA; Grummels, A; Derks, IA; Dolman, KM; Beaumont, T; Tedder, TF; van Noesel, CJ; Eldering, E; van Lier, RA. CD20 deficiency in humans results in impaired T cell-independent antibody responses. Journal of Clinical Investigation. 2010;120:214-222.  Abstract
  • Matsushita, T; Horikawa, M; Iwata, Y; Tedder, TF. Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. Journal of immunology (Baltimore, Md. : 1950). 2010;185:2240-2252.  Abstract
  • Nakashima, H; Hamaguchi, Y; Watanabe, R; Ishiura, N; Kuwano, Y; Okochi, H; Takahashi, Y; Tamaki, K; Sato, S; Tedder, TF; Fujimoto, M. CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions. Journal of immunology (Baltimore, Md. : 1950). 2010;184:4637-4645.  Abstract
  • Ogawa, A; Yoshizaki, A; Yanaba, K; Ogawa, F; Hara, T; Muroi, E; Takenaka, M; Shimizu, K; Hasegawa, M; Fujimoto, M; Tedder, TF; Sato, S. The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. Journal of Investigative Dermatology. 2010;130:1558-1570.  Abstract
  • Ohmatsu, H; Kadono, T; Sugaya, M; Tomita, M; Kai, H; Miyagaki, T; Saeki, H; Tamaki, K; Steeber, DA; Tedder, TF; Sato, S. ¿4ß7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin. Journal of Allergy and Clinical Immunology. 2010;126:1267-1276.  Abstract
  • Smith, SH; Haas, KM; Poe, JC; Yanaba, K; Ward, CD; Migone, TS; Tedder, TF. B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. International Immunology. 2010;22:681-691.  Abstract
  • Tedder, TF. Innate and adaptive receptors interact to balance humoral immunity. Journal of immunology (Baltimore, Md. : 1950). 2010;184:2231-2232.  Abstract
  • Tedder, TF; Matsushita, T. Regulatory B cells that produce IL-10: a breath of fresh air in allergic airway disease. Journal of Allergy and Clinical Immunology. 2010;125:1125-1127.  Abstract
  • Watanabe, R; Ishiura, N; Nakashima, H; Kuwano, Y; Okochi, H; Tamaki, K; Sato, S; Tedder, TF; Fujimoto, M. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. Journal of immunology (Baltimore, Md. : 1950). 2010;184:4801-4809.  Abstract
  • Yoshizaki, A; Yanaba, K; Iwata, Y; Komura, K; Ogawa, A; Akiyama, Y; Muroi, E; Hara, T; Ogawa, F; Takenaka, M; Shimizu, K; Hasegawa, M; Fujimoto, M; Tedder, TF; Sato, S. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. Journal of immunology (Baltimore, Md. : 1950). 2010;185:2502-2515.  Abstract
  • Chen, J; Crispín, JC; Tedder, TF; Dalle Lucca, J; Tsokos, GC. B cells contribute to ischemia/reperfusion-mediated tissue injury. Journal of Autoimmunity. 2009;32:195-200.  Abstract
  • Haas, KM; Poe, JC; Tedder, TF. CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. Journal of immunology (Baltimore, Md. : 1950). 2009;183:3661-3671.  Abstract
  • Ishii, T; Fujita, T; Matsushita, T; Yanaba, K; Hasegawa, M; Nakashima, H; Ogawa, F; Shimizu, K; Takehara, K; Tedder, TF; Sato, S; Fujimoto, M. Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. The American journal of pathology. 2009;174:2225-2233.  Abstract
  • Iwata, Y; Yoshizaki, A; Komura, K; Shimizu, K; Ogawa, F; Hara, T; Muroi, E; Bae, S; Takenaka, M; Yukami, T; Hasegawa, M; Fujimoto, M; Tomita, Y; Tedder, TF; Sato, S. CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. The American journal of pathology. 2009;175:649-660.  Abstract
  • James, SE; Orgun, NN; Tedder, TF; Shlomchik, MJ; Jensen, MC; Lin, Y; Greenberg, PD; Press, OW. Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood. 2009;114:5454-5463.  Abstract
  • Matsushita, T; Tedder, TF. B-lymphocyte depletion for the treatment of multiple sclerosis: now things really get interesting. Expert Review of Neurotherapeutics. 2009;9:309-312.  Abstract
  • Slack, E; Hapfelmeier, S; Stecher, B; Velykoredko, Y; Stoel, M; Lawson, MA; Geuking, MB; Beutler, B; Tedder, TF; Hardt, WD; Bercik, P; Verdu, EF; McCoy, KD; Macpherson, AJ. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science. 2009;325:617-620.  Abstract
  • Smith, SH; Tedder, TF. Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B?. Diabetes. 2009;58:1479-1481.  Abstract
  • Tedder, TF. CD19: a promising B cell target for rheumatoid arthritis. Nature Reviews Rheumatology. 2009;5:572-577.  Abstract
  • Yanaba, K; Bouaziz, JD; Matsushita, T; Tsubata, T; Tedder, TF. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. Journal of immunology (Baltimore, Md. : 1950). 2009;182:7459-7472.  Abstract
  • Aiba, Y; Kameyama, M; Yamazaki, T; Tedder, TF; Kurosaki, T. Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood. 2008;111:1497-1503.  Abstract
  • Bouaziz, JD; Yanaba, K; Tedder, TF. Regulatory B cells as inhibitors of immune responses and inflammation. Immunological Reviews. 2008;224:201-214.  Abstract
  • DiLillo, DJ; Hamaguchi, Y; Ueda, Y; Yang, K; Uchida, J; Haas, KM; Kelsoe, G; Tedder, TF. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. Journal of immunology (Baltimore, Md. : 1950). 2008;180:361-371.  Abstract
  • Komura, K; Yanaba, K; Horikawa, M; Ogawa, F; Fujimoto, M; Tedder, TF; Sato, S. CD19 regulates the development of bleomycin-induced pulmonary fibrosis in a mouse model. Arthritis and Rheumatism. 2008;58:3574-3584.  Abstract
  • LeBien, TW; Tedder, TF. B lymphocytes: how they develop and function. Blood. 2008;112:1570-1580.  Abstract
  • Matsushita, T; Yanaba, K; Bouaziz, JD; Fujimoto, M; Tedder, TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. Journal of Clinical Investigation. 2008;118:3420-3430.  Abstract
  • Minard-Colin, V; Xiu, Y; Poe, JC; Horikawa, M; Magro, CM; Hamaguchi, Y; Haas, KM; Tedder, TF. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood. 2008;112:1205-1213.  Abstract
  • Onodera, T; Poe, JC; Tedder, TF; Tsubata, T. CD22 regulates time course of both B cell division and antibody response. Journal of immunology (Baltimore, Md. : 1950). 2008;180:907-913.  Abstract
  • Prazma, CM; Tedder, TF. Dendritic cell CD83: a therapeutic target or innocent bystander?. Immunology Letters. 2008;115:1-8.  Abstract
  • Shigeta, A; Matsumoto, M; Tedder, TF; Lowe, JB; Miyasaka, M; Hirata, T. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. Blood. 2008;112:4915-4923.  Abstract
  • Xiu, Y; Wong, CP; Bouaziz, JD; Hamaguchi, Y; Wang, Y; Pop, SM; Tisch, RM; Tedder, TF. B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. Journal of immunology (Baltimore, Md. : 1950). 2008;180:2863-2875.  Abstract
  • Yanaba, K; Bouaziz, JD; Haas, KM; Poe, JC; Fujimoto, M; Tedder, TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008;28:639-650.  Abstract
  • Yanaba, K; Bouaziz, JD; Matsushita, T; Magro, CM; St Clair, EW; Tedder, TF. B-lymphocyte contributions to human autoimmune disease. Immunological Reviews. 2008;223:284-299.  Abstract
  • Yoshizaki, A; Iwata, Y; Komura, K; Ogawa, F; Hara, T; Muroi, E; Takenaka, M; Shimizu, K; Hasegawa, M; Fujimoto, M; Tedder, TF; Sato, S. CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. The American journal of pathology. 2008;172:1650-1663.  Abstract
  • Bouaziz, JD; Yanaba, K; Venturi, GM; Wang, Y; Tisch, RM; Poe, JC; Tedder, TF. Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proceedings of the National Academy of Sciences of USA. 2007;104:20878-20883.  Abstract
  • Hayakawa, I; Tedder, TF; Zhuang, Y. B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice. Immunology. 2007;122:73-79.  Abstract
  • Kuwano, Y; Prazma, CM; Yazawa, N; Watanabe, R; Ishiura, N; Kumanogoh, A; Okochi, H; Tamaki, K; Fujimoto, M; Tedder, TF. CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. International Immunology. 2007;19:977-992.  Abstract
  • Matsushita, Y; Hasegawa, M; Matsushita, T; Fujimoto, M; Horikawa, M; Fujita, T; Kawasuji, A; Ogawa, F; Steeber, DA; Tedder, TF; Takehara, K; Sato, S. Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Journal of immunology (Baltimore, Md. : 1950). 2007;179:698-707.  Abstract
  • Prazma, CM; Yazawa, N; Fujimoto, Y; Fujimoto, M; Tedder, TF. CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. Journal of immunology (Baltimore, Md. : 1950). 2007;179:4550-4562.  Abstract
  • Venturi, GM; Conway, RM; Steeber, DA; Tedder, TF. CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. Journal of immunology (Baltimore, Md. : 1950). 2007;178:291-300.  Abstract
  • Watanabe, R; Fujimoto, M; Ishiura, N; Kuwano, Y; Nakashima, H; Yazawa, N; Okochi, H; Sato, S; Tedder, TF; Tamaki, K. CD19 expression in B cells is important for suppression of contact hypersensitivity. The American journal of pathology. 2007;171:560-570.  Abstract
  • Yanaba, K; Hamaguchi, Y; Venturi, GM; Steeber, DA; St Clair, EW; Tedder, TF. B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. Journal of immunology (Baltimore, Md. : 1950). 2007;179:1369-1380.  Abstract
  • Yukami, T; Hasegawa, M; Matsushita, Y; Fujita, T; Matsushita, T; Horikawa, M; Komura, K; Yanaba, K; Hamaguchi, Y; Nagaoka, T; Ogawa, F; Fujimoto, M; Steeber, DA; Tedder, TF; Takehara, K; Sato, S. Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Journal of leukocyte biology. 2007;82:519-531.  Abstract
  • Zabel, MD; Heikenwalder, M; Prinz, M; Arrighi, I; Schwarz, P; Kranich, J; von Teichman, A; Haas, KM; Zeller, N; Tedder, TF; Weis, JH; Aguzzi, A. Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. Journal of immunology (Baltimore, Md. : 1950). 2007;179:6144-6152.  Abstract
  • Adamson, PJ; Millard, DJ; Hohmann, AW; Mavrangelos, C; Macardle, PJ; Pilkington, G; Mulhern, TD; Tedder, TF; Zola, H; Nicholson, IC. Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1. Molecular Immunology. 2006;43:550-558.  Abstract
  • Fujimoto, M; Kuwano, Y; Watanabe, R; Asashima, N; Nakashima, H; Yoshitake, S; Okochi, H; Tamaki, K; Poe, JC; Tedder, TF; Sato, S. B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. Journal of immunology (Baltimore, Md. : 1950). 2006;176:873-879.  Abstract
  • Fujimoto, Y; Tedder, TF. CD83: a regulatory molecule of the immune system with great potential for therapeutic application. Journal of medical and dental sciences. 2006;53:85-91.  Abstract
  • Haas, KM; Sen, S; Sanford, IG; Miller, AS; Poe, JC; Tedder, TF. CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. Journal of immunology (Baltimore, Md. : 1950). 2006;177:3063-3073.  Abstract
  • Hamaguchi, Y; Xiu, Y; Komura, K; Nimmerjahn, F; Tedder, TF. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. The Journal of Experimental Medicine. 2006;203:743-753.  Abstract
  • Hasegawa, M; Hamaguchi, Y; Yanaba, K; Bouaziz, JD; Uchida, J; Fujimoto, M; Matsushita, T; Matsushita, Y; Horikawa, M; Komura, K; Takehara, K; Sato, S; Tedder, TF. B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. The American journal of pathology. 2006;169:954-966.  Abstract
  • Inaoki, M; Echigo, T; Hayashi, H; Nagaoka, T; Hasegawa, M; Takehara, K; Fujimoto, W; Tedder, TF; Sato, S. Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. Journal of Autoimmunity. 2006;27:196-202.  Abstract
  • Kawasuji, A; Hasegawa, M; Horikawa, M; Fujita, T; Matsushita, Y; Matsushita, T; Fujimoto, M; Steeber, DA; Tedder, TF; Takehara, K; Sato, S. L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury. Journal of leukocyte biology. 2006;79:696-705.  Abstract
  • Matsushita, T; Fujimoto, M; Hasegawa, M; Komura, K; Takehara, K; Tedder, TF; Sato, S. Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. The American journal of pathology. 2006;168:812-821.  Abstract
  • Pieper, M; Scheffold, C; Duwe, S; Rossig, C; Bisping, G; Stelljes, M; Tedder, TF; Jurgens, H; Berdel, WE; Kienast, J. Immunotherapy of B-cell malignancies with genetically engineered human CD8+ natural killer T cells. Leukemia. 2006;20:729-732.  Abstract
  • St Clair, EW; Tedder, TF. New prospects for autoimmune disease therapy: B cells on deathwatch. Arthritis and Rheumatism. 2006;54:1-9.  Abstract
  • Tedder, TF; Baras, A; Xiu, Y. Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity. Springer seminars in immunopathology. 2006;28:351-364.  Abstract
  • Yamada, M; Yanaba, K; Hasegawa, M; Matsushita, Y; Horikawa, M; Komura, K; Matsushita, T; Kawasuji, A; Fujita, T; Takehara, K; Steeber, DA; Tedder, TF; Sato, S. Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. Clinical & Experimental Immunology. 2006;143:216-227.  Abstract
  • Haas, KM; Poe, JC; Steeber, DA; Tedder, TF. B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity. 2005;23:7-18.  Abstract
  • Haas, KM; Tedder, TF. Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity. Advances in experimental medicine and biology. 2005;560:125-139.  Abstract
  • Hamaguchi, Y; Uchida, J; Cain, DW; Venturi, GM; Poe, JC; Haas, KM; Tedder, TF. The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. Journal of immunology (Baltimore, Md. : 1950). 2005;174:4389-4399.  Abstract
  • Lee, Y; Haas, KM; Gor, DO; Ding, X; Karp, DR; Greenspan, NS; Poe, JC; Tedder, TF. Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. Journal of immunology (Baltimore, Md. : 1950). 2005;175:8011-8023.  Abstract
  • Steeber, DA; Venturi, GM; Tedder, TF. A new twist to the leukocyte adhesion cascade: intimate cooperation is key. Trends in Immunology. 2005;26:9-12.  Abstract
  • Stohl, W; Xu, D; Kim, KS; Tedder, TF; Sato, S. Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II. Clinical Immunology. 2005;116:257-264.  Abstract
  • Tedder, TF; Poe, JC; Fujimoto, M; Haas, KM; Sato, S. The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. Current directions in autoimmunity. 2005;8:55-90.  Abstract
  • Tedder, TF; Poe, JC; Haas, KM. CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Advances in immunology. 2005;88:1-50.  Abstract
  • Yazawa, N; Hamaguchi, Y; Poe, JC; Tedder, TF. Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proceedings of the National Academy of Sciences of USA. 2005;102:15178-15183.  Abstract
  • Zola, H; Swart, B; Nicholson, I; Aasted, B; Bensussan, A; Boumsell, L; Buckley, C; Clark, G; Drbal, K; Engel, P; Hart, D; Horejsí, V; Isacke, C; Macardle, P; Malavasi, F; Mason, D; Olive, D; Saalmueller, A; Schlossman, SF; Schwartz-Albiez, R; Simmons, P; Tedder, TF; Uguccioni, M; Warren, H. CD molecules 2005: human cell differentiation molecules. Blood. 2005;106:3123-3126.  Abstract
  • Asano, N; Fujimoto, M; Yazawa, N; Shirasawa, S; Hasegawa, M; Okochi, H; Tamaki, K; Tedder, TF; Sato, S. B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. The American journal of pathology. 2004;165:641-650.  Abstract
  • Haas, KM; Toapanta, FR; Oliver, JA; Poe, JC; Weis, JH; Karp, DR; Bower, JF; Ross, TM; Tedder, TF. Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression. Journal of immunology (Baltimore, Md. : 1950). 2004;172:5833-5837.  Abstract
  • Ma-Krupa, W; Jeon, MS; Spoerl, S; Tedder, TF; Goronzy, JJ; Weyand, CM. Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. The Journal of Experimental Medicine. 2004;199:173-183.  Abstract
  • Ogawa, D; Shikata, K; Honke, K; Sato, S; Matsuda, M; Nagase, R; Tone, A; Okada, S; Usui, H; Wada, J; Miyasaka, M; Kawashima, H; Suzuki, Y; Suzuki, T; Taniguchi, N; Hirahara, Y; Tadano-Aritomi, K; Ishizuka, I; Tedder, TF; Makino, H. Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction. The Journal of biological chemistry. 2004;279:2085-2090.  Abstract
  • Poe, JC; Fujimoto, Y; Hasegawa, M; Haas, KM; Miller, AS; Sanford, IG; Bock, CB; Fujimoto, M; Tedder, TF. CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. Nature Immunology. 2004;5:1078-1087.  Abstract
  • Poe, JC; Haas, KM; Uchida, J; Lee, Y; Fujimoto, M; Tedder, TF. Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. Journal of immunology (Baltimore, Md. : 1950). 2004;172:2100-2110.  Abstract
  • Sato, S; Fujimoto, M; Hasegawa, M; Takehara, K; Tedder, TF. Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. Molecular Immunology. 2004;41:1123-1133.  Abstract
  • Tsuchiya, N; Kuroki, K; Fujimoto, M; Murakami, Y; Tedder, TF; Tokunaga, K; Takehara, K; Sato, S. Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis. Arthritis and Rheumatism. 2004;50:4002-4007.  Abstract
  • Uchida, J; Hamaguchi, Y; Oliver, JA; Ravetch, JV; Poe, JC; Haas, KM; Tedder, TF. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. The Journal of Experimental Medicine. 2004;199:1659-1669.  Abstract
  • Uchida, J; Lee, Y; Hasegawa, M; Liang, Y; Bradney, A; Oliver, JA; Bowen, K; Steeber, DA; Haas, KM; Poe, JC; Tedder, TF. Mouse CD20 expression and function. International Immunology. 2004;16:119-129.  Abstract
  • Galkina, E; Tanousis, K; Preece, G; Tolaini, M; Kioussis, D; Florey, O; Haskard, DO; Tedder, TF; Ager, A. L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. The Journal of Experimental Medicine. 2003;198:1323-1335.  Abstract
  • Komura, K; Hasegawa, M; Hamaguchi, Y; Saito, E; Kaburagi, Y; Yanaba, K; Kawara, S; Takehara, K; Seki, M; Steeber, DA; Tedder, TF; Sato, S. Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. Journal of immunology (Baltimore, Md. : 1950). 2003;171:2855-2862.  Abstract
  • Shimada, Y; Hasegawa, M; Kaburagi, Y; Hamaguchi, Y; Komura, K; Saito, E; Takehara, K; Steeber, DA; Tedder, TF; Sato, S. L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. Journal of immunology (Baltimore, Md. : 1950). 2003;170:4325-4334.  Abstract
  • Shoham, T; Rajapaksa, R; Boucheix, C; Rubinstein, E; Poe, JC; Tedder, TF; Levy, S. The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. Journal of immunology (Baltimore, Md. : 1950). 2003;171:4062-4072.  Abstract
  • Tedder, TF; Dawson, JR. In memoriam. D. Bernard Amos April 16, 1923-May 15, 2003. Journal of immunology (Baltimore, Md. : 1950). 2003;171:6316-6317.  Abstract
  • Tuscano, JM; Harris, GS; Tedder, TF. B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications. Autoimmunity Reviews. 2003;2:101-108.  Abstract
  • Tuscano, JM; O'Donnell, RT; Miers, LA; Kroger, LA; Kukis, DL; Lamborn, KR; Tedder, TF; DeNardo, GL. Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts. Blood. 2003;101:3641-3647.  Abstract
  • Venturi, GM; Tu, L; Kadono, T; Khan, AI; Fujimoto, Y; Oshel, P; Bock, CB; Miller, AS; Albrecht, RM; Kubes, P; Steeber, DA; Tedder, TF. Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity. 2003;19:713-724.  Abstract
  • Yanaba, K; Kaburagi, Y; Takehara, K; Steeber, DA; Tedder, TF; Sato, S. Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. The American journal of pathology. 2003;162:1463-1473.  Abstract
  • Yazawa, N; Fujimoto, M; Sato, S; Miyake, K; Asano, N; Nagai, Y; Takeuchi, O; Takeda, K; Okochi, H; Akira, S; Tedder, TF; Tamaki, K. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood. 2003;102:1374-1380.  Abstract
  • Dwir, O; Steeber, DA; Schwarz, US; Camphausen, RT; Kansas, GS; Tedder, TF; Alon, R. L-selectin dimerization enhances tether formation to properly spaced ligand. The Journal of biological chemistry. 2002;277:21130-21139.  Abstract
  • Friedline, RH; Wong, CP; Steeber, DA; Tedder, TF; Tisch, R. L-selectin is not required for T cell-mediated autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950). 2002;168:2659-2666.  Abstract
  • Fujimoto, M; Poe, JC; Satterthwaite, AB; Wahl, MI; Witte, ON; Tedder, TF. Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. Journal of immunology (Baltimore, Md. : 1950). 2002;168:5465-5476.  Abstract
  • Fujimoto, Y; Tu, L; Miller, AS; Bock, C; Fujimoto, M; Doyle, C; Steeber, DA; Tedder, TF. CD83 expression influences CD4+ T cell development in the thymus. Cell. 2002;108:755-767.  Abstract
  • Haas, KM; Hasegawa, M; Steeber, DA; Poe, JC; Zabel, MD; Bock, CB; Karp, DR; Briles, DE; Weis, JH; Tedder, TF. Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. Immunity. 2002;17:713-723.  Abstract
  • Hamaguchi, Y; Nishizawa, Y; Yasui, M; Hasegawa, M; Kaburagi, Y; Komura, K; Nagaoka, T; Saito, E; Shimada, Y; Takehara, K; Kadono, T; Steeber, DA; Tedder, TF; Sato, S. Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. The American journal of pathology. 2002;161:1607-1618.  Abstract
  • Kaburagi, Y; Hasegawa, M; Nagaoka, T; Shimada, Y; Hamaguchi, Y; Komura, K; Saito, E; Yanaba, K; Takehara, K; Kadono, T; Steeber, DA; Tedder, TF; Sato, S. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. Journal of immunology (Baltimore, Md. : 1950). 2002;168:2970-2978.  Abstract
  • Kadono, T; Venturi, GM; Steeber, DA; Tedder, TF. Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. Journal of immunology (Baltimore, Md. : 1950). 2002;169:4542-4550.  Abstract
  • Saito, E; Fujimoto, M; Hasegawa, M; Komura, K; Hamaguchi, Y; Kaburagi, Y; Nagaoka, T; Takehara, K; Tedder, TF; Sato, S. CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. Journal of Clinical Investigation. 2002;109:1453-1462.  Abstract
  • Tedder, TF; Haas, KM; Poe, JC. CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses. Biochemical Society transactions. 2002;30:807-811.  Abstract
  • Tu, L; Poe, JC; Kadono, T; Venturi, GM; Bullard, DC; Tedder, TF; Steeber, DA. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. Journal of immunology (Baltimore, Md. : 1950). 2002;169:2034-2043.  Abstract
  • Fiscus, LC; Van Herpen, J; Steeber, DA; Tedder, TF; Tang, ML. L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma. Journal of Allergy and Clinical Immunology. 2001;107:1019-1024.  Abstract
  • Fujimoto, M; Poe, JC; Hasegawa, M; Tedder, TF. CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. The Journal of biological chemistry. 2001;276:44820-44827.  Abstract
  • Hasegawa, M; Fujimoto, M; Poe, JC; Steeber, DA; Lowell, CA; Tedder, TF. A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. Journal of immunology (Baltimore, Md. : 1950). 2001;167:2469-2478.  Abstract
  • Hasegawa, M; Fujimoto, M; Poe, JC; Steeber, DA; Tedder, TF. CD19 can regulate B lymphocyte signal transduction independent of complement activation. Journal of immunology (Baltimore, Md. : 1950). 2001;167:3190-3200.  Abstract
  • Keramidaris, E; Merson, TD; Steeber, DA; Tedder, TF; Tang, ML. L-selectin and intercellular adhesion molecule 1 mediate lymphocyte migration to the inflamed airway/lung during an allergic inflammatory response in an animal model of asthma. Journal of Allergy and Clinical Immunology. 2001;107:734-738.  Abstract
  • Leid, JG; Steeber, DA; Tedder, TF; Jutila, MA. Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. Journal of immunology (Baltimore, Md. : 1950). 2001;166:4899-4907.  Abstract
  • Li, X; Tu, L; Murphy, PG; Kadono, T; Steeber, DA; Tedder, TF. CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. Journal of leukocyte biology. 2001;69:565-574.  Abstract
  • Liang, Y; Buckley, TR; Tu, L; Langdon, SD; Tedder, TF. Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics. 2001;53:357-368.  Abstract
  • Liang, Y; Tedder, TF. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-127.  Abstract
  • Poe, JC; Hasegawa, M; Tedder, TF. CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. International Reviews of Immunology (Informa). 2001;20:739-762.  Abstract
  • Qian, Y; Santiago, C; Borrero, M; Tedder, TF; Clarke, SH. Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. Journal of immunology (Baltimore, Md. : 1950). 2001;166:2412-2419.  Abstract
  • Tedder, TF; Jansen, PJ. Isolation and generation of human dendritic cells. Current Protocols in Immunology. 2001;Chapter 7:Unit 7.32.  Abstract
  • Fujimoto, M; Fujimoto, Y; Poe, JC; Jansen, PJ; Lowell, CA; DeFranco, AL; Tedder, TF. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity. 2000;13:47-57.  Abstract
  • Fujimoto, M; Poe, JC; Hasegawa, M; Tedder, TF. CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. Immunologic Research. 2000;22:281-298.  Abstract
  • Gommerman, JL; Oh, DY; Zhou, X; Tedder, TF; Maurer, M; Galli, SJ; Carroll, MC. A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. Journal of immunology (Baltimore, Md. : 1950). 2000;165:6915-6921.  Abstract
  • Inaoki, M; Sato, S; Shimada, Y; Kawara, S; Steeber, DA; Tedder, TF; Takehara, K. Decreased expression levels of L-selectin on subsets of leucocytes and increased serum L-selectin in severe psoriasis. Clinical & Experimental Immunology. 2000;122:484-492.  Abstract
  • Langdon, SD; Inaioki, M; Kelsoe, G; Tedder, TF. Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution. Immunogenetics. 2000;51:241-245.  Abstract
  • McKinsey, TA; Chu, Z; Tedder, TF; Ballard, DW. Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. Molecular Immunology. 2000;37:783-788.  Abstract
  • Nagaoka, T; Kaburagi, Y; Hamaguchi, Y; Hasegawa, M; Takehara, K; Steeber, DA; Tedder, TF; Sato, S. Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. The American journal of pathology. 2000;157:237-247.  Abstract
  • Poe, JC; Fujimoto, M; Jansen, PJ; Miller, AS; Tedder, TF. CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. The Journal of biological chemistry. 2000;275:17420-17427.  Abstract
  • Sato, S; Hasegawa, M; Fujimoto, M; Tedder, TF; Takehara, K. Quantitative genetic variation in CD19 expression correlates with autoimmunity. Journal of immunology (Baltimore, Md. : 1950). 2000;165:6635-6643.  Abstract
  • Satterthwaite, AB; Willis, F; Kanchanastit, P; Fruman, D; Cantley, LC; Helgason, CD; Humphries, RK; Lowell, CA; Simon, M; Leitges, M; Tarakhovsky, A; Tedder, TF; Lesche, R; Wu, H; Witte, ON. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proceedings of the National Academy of Sciences of USA. 2000;97:6687-6692.  Abstract
  • Steeber, DA; Tedder, TF. Adhesion molecule cascades direct lymphocyte recirculation and leukocyte migration during inflammation. Immunologic Research. 2000;22:299-317.  Abstract
  • Tedder, TF; Sato, S; Poe, JC; Fujimoto, M. CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity. The Keio journal of medicine. 2000;49:1-13.  Abstract
  • Ward, FE; Tedder, TF. Immunology at Duke. Immunologic Research. 2000;22:67-69.  Abstract
  • Yan, ZQ; Bolognesi, MP; Steeber, DA; Tedder, TF; Chen, LE; Seaber, AV; Urbaniak, JR. Blockade of L-selectin attenuates reperfusion injury in a rat model. Journal of Reconstructive Microsurgery. 2000;16:227-233.  Abstract
  • Zipfel, PA; Grove, M; Blackburn, K; Fujimoto, M; Tedder, TF; Pendergast, AM. The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. Journal of immunology (Baltimore, Md. : 1950). 2000;165:6872-6879.  Abstract
  • Fujimoto, M; Bradney, AP; Poe, JC; Steeber, DA; Tedder, TF. Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop. Immunity. 1999;11:191-200.  Abstract
  • Fujimoto, M; Poe, JC; Jansen, PJ; Sato, S; Tedder, TF. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. Journal of immunology (Baltimore, Md. : 1950). 1999;162:7088-7094.  Abstract
  • Kanwar, S; Steeber, DA; Tedder, TF; Hickey, MJ; Kubes, P. Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculature. Journal of immunology (Baltimore, Md. : 1950). 1999;162:2709-2716.  Abstract
  • Li, X; Tedder, TF. CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. Genomics. 1999;55:345-347.  Abstract
  • Shimada, Y; Sato, S; Hasegawa, M; Tedder, TF; Takehara, K. Elevated serum L-selectin levels and abnormal regulation of L-selectin expression on leukocytes in atopic dermatitis: soluble L-selectin levels indicate disease severity. Journal of Allergy and Clinical Immunology. 1999;104:163-168.  Abstract
  • Sieling, PA; Jullien, D; Dahlem, M; Tedder, TF; Rea, TH; Modlin, RL; Porcelli, SA. CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. Journal of immunology (Baltimore, Md. : 1950). 1999;162:1851-1858.  Abstract
  • Steeber, DA; Tang, ML; Green, NE; Zhang, XQ; Sloane, JE; Tedder, TF. Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. Journal of immunology (Baltimore, Md. : 1950). 1999;163:2176-2186.  Abstract
  • Tu, L; Delahunty, MD; Ding, H; Luscinskas, FW; Tedder, TF. The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. The Journal of Experimental Medicine. 1999;189:241-252.  Abstract
  • Tu, L; Murphy, PG; Li, X; Tedder, TF. L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. Journal of immunology (Baltimore, Md. : 1950). 1999;163:5070-5078.  Abstract
  • Tuscano, JM; Riva, A; Toscano, SN; Tedder, TF; Kehrl, JH. CD22 cross-linking generates B-cell antigen receptor-independent signals that activate the JNK/SAPK signaling cascade. Blood. 1999;94:1382-1392.  Abstract
  • Yadav, SS; Howell, DN; Steeber, DA; Harland, RC; Tedder, TF; Clavien, PA. P-Selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver. Hepatology. 1999;29:1494-1502.  Abstract
  • Fong, AM; Robinson, LA; Steeber, DA; Tedder, TF; Yoshie, O; Imai, T; Patel, DD. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. The Journal of Experimental Medicine. 1998;188:1413-1419.  Abstract
  • Fujimoto, M; Poe, JC; Inaoki, M; Tedder, TF. CD19 regulates B lymphocyte responses to transmembrane signals. Seminars in Immunology. 1998;10:267-277.  Abstract
  • Kunkel, EJ; Ramos, CL; Steeber, DA; Müller, W; Wagner, N; Tedder, TF; Ley, K. The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. Journal of immunology (Baltimore, Md. : 1950). 1998;161:2449-2456.  Abstract
  • Li, X; Steeber, DA; Tang, ML; Farrar, MA; Perlmutter, RM; Tedder, TF. Regulation of L-selectin-mediated rolling through receptor dimerization. The Journal of Experimental Medicine. 1998;188:1385-1390.  Abstract
  • Robinson, LA; Tu, L; Steeber, DA; Preis, O; Platt, JL; Tedder, TF. The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. Journal of immunology (Baltimore, Md. : 1950). 1998;161:6931-6938.  Abstract
  • Sato, S; Tuscano, JM; Inaoki, M; Tedder, TF. CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. Seminars in Immunology. 1998;10:287-297.  Abstract
  • Steeber, DA; Campbell, MA; Basit, A; Ley, K; Tedder, TF. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proceedings of the National Academy of Sciences of USA. 1998;95:7562-7567.  Abstract
  • Steeber, DA; Tang, ML; Zhang, XQ; Müller, W; Wagner, N; Tedder, TF. Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. Journal of immunology (Baltimore, Md. : 1950). 1998;161:6638-6647.  Abstract
  • Tang, ML; Steeber, DA; Zhang, XQ; Tedder, TF. Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways. Journal of immunology (Baltimore, Md. : 1950). 1998;160:5113-5121.  Abstract
  • Tedder, TF. Introduction: response-regulators of B lymphocyte signaling thresholds provide a context for antigen receptor signal transduction. Seminars in Immunology. 1998;10:259-265.  Abstract
  • Twist, CJ; Beier, DR; Disteche, CM; Edelhoff, S; Tedder, TF. The mouse Cd83 gene: structure, domain organization, and chromosome localization. Immunogenetics. 1998;48:383-393.  Abstract
  • Wagner, N; Löhler, J; Tedder, TF; Rajewsky, K; Müller, W; Steeber, DA. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. European Journal of Immunology. 1998;28:3832-3839.  Abstract
  • Allport, JR; Ding, HT; Ager, A; Steeber, DA; Tedder, TF; Luscinskas, FW. L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro. Journal of immunology (Baltimore, Md. : 1950). 1997;158:4365-4372.  Abstract
  • Davenpeck, KL; Steeber, DA; Tedder, TF; Bochner, BS. P- and L-selectin mediate distinct but overlapping functions in endotoxin-induced leukocyte-endothelial interactions in the rat mesenteric microcirculation. Journal of immunology (Baltimore, Md. : 1950). 1997;159:1977-1986.  Abstract
  • Doyle, NA; Bhagwan, SD; Meek, BB; Kutkoski, GJ; Steeber, DA; Tedder, TF; Doerschuk, CM. Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice. Journal of Clinical Investigation. 1997;99:526-533.  Abstract
  • Fryer, AD; Costello, RW; Yost, BL; Lobb, RR; Tedder, TF; Steeber, DA; Bochner, BS. Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways. Journal of Clinical Investigation. 1997;99:2036-2044.  Abstract
  • Haribabu, B; Steeber, DA; Ali, H; Richardson, RM; Snyderman, R; Tedder, TF. Chemoattractant receptor-induced phosphorylation of L-selectin. The Journal of biological chemistry. 1997;272:13961-13965.  Abstract
  • Inaoki, M; Sato, S; Weintraub, BC; Goodnow, CC; Tedder, TF. CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. The Journal of Experimental Medicine. 1997;186:1923-1931.  Abstract
  • Morse, MA; Zhou, LJ; Tedder, TF; Lyerly, HK; Smith, C. Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy. Annals of Surgery. 1997;226:6-16.  Abstract
  • Sato, S; Jansen, PJ; Tedder, TF. CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proceedings of the National Academy of Sciences of USA. 1997;94:13158-13162.  Abstract
  • Sato, S; Miller, AS; Howard, MC; Tedder, TF. Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. Journal of immunology (Baltimore, Md. : 1950). 1997;159:3278-3287.  Abstract
  • Sato, S; Steeber, DA; Jansen, PJ; Tedder, TF. CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. Journal of immunology (Baltimore, Md. : 1950). 1997;158:4662-4669.  Abstract
  • Steeber, DA; Engel, P; Miller, AS; Sheetz, MP; Tedder, TF. Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes. Journal of immunology (Baltimore, Md. : 1950). 1997;159:952-963.  Abstract
  • Tang, ML; Hale, LP; Steeber, DA; Tedder, TF. L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. Journal of immunology (Baltimore, Md. : 1950). 1997;158:5191-5199.  Abstract
  • Tedder, TF; Inaoki, M; Sato, S. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity. 1997;6:107-118.  Abstract
  • Tedder, TF; Tuscano, J; Sato, S; Kehrl, JH. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Annual Review of Immunology. 1997;15:481-504.  Abstract
  • Fanger, NA; Wardwell, K; Shen, L; Tedder, TF; Guyre, PM. Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 1996;157:541-548.  Abstract
  • Jung, U; Bullard, DC; Tedder, TF; Ley, K. Velocity differences between L- and P-selectin-dependent neutrophil rolling in venules of mouse cremaster muscle in vivo. The American journal of physiology. 1996;271:H2740-H2747.  Abstract
  • Laszik, Z; Jansen, PJ; Cummings, RD; Tedder, TF; McEver, RP; Moore, KL. P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. Blood. 1996;88:3010-3021.  Abstract
  • Luscinskas, FW; Ding, H; Tan, P; Cumming, D; Tedder, TF; Gerritsen, ME. L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. Journal of immunology (Baltimore, Md. : 1950). 1996;157:326-335.  Abstract
  • Munro, JM; Briscoe, DM; Tedder, TF. Differential regulation of leucocyte L-selectin (CD62L) expression in normal lymphoid and inflamed extralymphoid tissues. Journal of Clinical Pathology. 1996;49:721-727.  Abstract
  • Ramamoorthy, C; Sharar, SR; Harlan, JM; Tedder, TF; Winn, RK. Blocking L-selectin function attenuates reperfusion injury following hemorrhagic shock in rabbits. The American journal of physiology. 1996;271:H1871-H1877.  Abstract
  • Sato, S; Miller, AS; Inaoki, M; Bock, CB; Jansen, PJ; Tang, ML; Tedder, TF. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity. 1996;5:551-562.  Abstract
  • Sato, S; Ono, N; Steeber, DA; Pisetsky, DS; Tedder, TF. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. Journal of immunology (Baltimore, Md. : 1950). 1996;157:4371-4378.  Abstract
  • Sharar, SR; Chapman, NN; Flaherty, LC; Harlan, JM; Tedder, TF; Winn, RK. L-selectin (CD62L) blockade does not impair peritoneal neutrophil emigration or subcutaneous host defense to bacteria in rabbits. Journal of immunology (Baltimore, Md. : 1950). 1996;157:2555-2563.  Abstract
  • Steeber, DA; Green, NE; Sato, S; Tedder, TF. Humoral immune responses in L-selectin-deficient mice. Journal of immunology (Baltimore, Md. : 1950). 1996;157:4899-4907.  Abstract
  • Steeber, DA; Green, NE; Sato, S; Tedder, TF. Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system. Journal of immunology (Baltimore, Md. : 1950). 1996;157:1096-1106.  Abstract
  • Tu, L; Chen, A; Delahunty, MD; Moore, KL; Watson, SR; McEver, RP; Tedder, TF. L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. Journal of immunology (Baltimore, Md. : 1950). 1996;157:3995-4004.  Abstract
  • Tuscano, J; Engel, P; Tedder, TF; Kehrl, JH. Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. Blood. 1996;87:4723-4730.  Abstract
  • Tuscano, JM; Engel, P; Tedder, TF; Agarwal, A; Kehrl, JH. Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. European Journal of Immunology. 1996;26:1246-1252.  Abstract
  • Zhou, LJ; Tedder, TF. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proceedings of the National Academy of Sciences of USA. 1996;93:2588-2592.  Abstract
  • Chen, A; Engel, P; Tedder, TF. Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. The Journal of Experimental Medicine. 1995;182:519-530.  Abstract
  • Engel, P; Wagner, N; Miller, AS; Tedder, TF. Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. The Journal of Experimental Medicine. 1995;181:1581-1586.  Abstract
  • Engel, P; Zhou, LJ; Ord, DC; Sato, S; Koller, B; Tedder, TF. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity. 1995;3:39-50.  Abstract
  • Gibson, RM; Kansas, GS; Tedder, TF; Furie, B; Furie, BC. Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. Blood. 1995;85:151-158.  Abstract
  • Ley, K; Bullard, DC; Arbonés, ML; Bosse, R; Vestweber, D; Tedder, TF; Beaudet, AL. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. The Journal of Experimental Medicine. 1995;181:669-675.  Abstract
  • Ley, K; Tedder, TF. Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. Journal of immunology (Baltimore, Md. : 1950). 1995;155:525-528.  Abstract
  • Rabb, H; Agosti, SJ; Bittle, PA; Fernandez, M; Ramirez, G; Tedder, TF. Alterations in soluble and leukocyte surface L-selectin (CD 62L) in hemodialysis patients. Journal of the American Society of Nephrology : JASN. 1995;6:1445-1450.  Abstract
  • Sato, S; Steeber, DA; Tedder, TF. The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proceedings of the National Academy of Sciences of USA. 1995;92:11558-11562.  Abstract
  • Tedder, TF; Steeber, DA; Chen, A; Engel, P. The selectins: vascular adhesion molecules. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1995;9:866-873.  Abstract
  • Tedder, TF; Steeber, DA; Pizcueta, P. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. The Journal of Experimental Medicine. 1995;181:2259-2264.  Abstract
  • Weissman, D; Li, Y; Ananworanich, J; Zhou, LJ; Adelsberger, J; Tedder, TF; Baseler, M; Fauci, AS. Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of USA. 1995;92:826-830.  Abstract
  • Zhou, LJ; Tedder, TF. A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. Blood. 1995;86:3295-3301.  Abstract
  • Zhou, LJ; Tedder, TF. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. Journal of immunology (Baltimore, Md. : 1950). 1995;154:3821-3835.  Abstract
  • Arbonés, ML; Ord, DC; Ley, K; Ratech, H; Maynard-Curry, C; Otten, G; Capon, DJ; Tedder, TF. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity. 1994;1:247-260.  Abstract
  • Donnelly, SC; Haslett, C; Dransfield, I; Robertson, CE; Carter, DC; Ross, JA; Grant, IS; Tedder, TF. Role of selectins in development of adult respiratory distress syndrome. The Lancet. 1994;344:215-219.  Abstract
  • Engel, P; Gribben, JG; Freeman, GJ; Zhou, LJ; Nozawa, Y; Abe, M; Nadler, LM; Wakasa, H; Tedder, TF. The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood. 1994;84:1402-1407.  Abstract
  • Engel, P; Tedder, TF. New CD from the B cell section of the Fifth International Workshop on Human Leukocyte Differentiation Antigens. Leukemia & Lymphoma (Informa). 1994;13 Suppl 1:61-64.  Abstract
  • Kansas, GS; Saunders, KB; Ley, K; Zakrzewicz, A; Gibson, RM; Furie, BC; Furie, B; Tedder, TF. A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion. The Journal of Cell Biology. 1994;124:609-618.  Abstract
  • Knol, EF; Tackey, F; Tedder, TF; Klunk, DA; Bickel, CA; Sterbinsky, SA; Bochner, BS. Comparison of human eosinophil and neutrophil adhesion to endothelial cells under nonstatic conditions. Role of L-selectin. Journal of immunology (Baltimore, Md. : 1950). 1994;153:2161-2167.  Abstract
  • Luscinskas, FW; Kansas, GS; Ding, H; Pizcueta, P; Schleiffenbaum, BE; Tedder, TF; Gimbrone, MA. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. The Journal of Cell Biology. 1994;125:1417-1427.  Abstract
  • Mihelcic, D; Schleiffenbaum, B; Tedder, TF; Sharar, SR; Harlan, JM; Winn, RK. Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear. Blood. 1994;84:2322-2328.  Abstract
  • Ord, DC; Edelhoff, S; Dushkin, H; Zhou, LJ; Beier, DR; Disteche, C; Tedder, TF. CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7. Immunogenetics. 1994;39:322-328.  Abstract
  • Tedder, TF; Engel, P. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunology Today. 1994;15:450-454.  Abstract
  • Tedder, TF; Zhou, LJ; Engel, P. The CD19/CD21 signal transduction complex of B lymphocytes. Immunology Today. 1994;15:437-442.  Abstract
  • Vonderheide, RH; Tedder, TF; Springer, TA; Staunton, DE. Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. The Journal of Cell Biology. 1994;125:215-222.  Abstract
  • Wagner, N; Engel, P; Vega, M; Tedder, TF. Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1994;152:5275-5287.  Abstract
  • Zhou, LJ; Smith, HM; Waldschmidt, TJ; Schwarting, R; Daley, J; Tedder, TF. Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development. Molecular and Cellular Biology. 1994;14:3884-3894.  Abstract
  • Bradbury, LE; Goldmacher, VS; Tedder, TF. The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. Journal of immunology (Baltimore, Md. : 1950). 1993;151:2915-2927.  Abstract
  • Bubien, JK; Zhou, LJ; Bell, PD; Frizzell, RA; Tedder, TF. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. The Journal of Cell Biology. 1993;121:1121-1132.  Abstract
  • Engel, P; Nojima, Y; Rothstein, D; Zhou, LJ; Wilson, GL; Kehrl, JH; Tedder, TF. The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes. Journal of immunology (Baltimore, Md. : 1950). 1993;150:4719-4732.  Abstract
  • Kansas, GS; Ley, K; Munro, JM; Tedder, TF. Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin. The Journal of Experimental Medicine. 1993;177:833-838.  Abstract
  • Ley, K; Tedder, TF; Kansas, GS. L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. Blood. 1993;82:1632-1638.  Abstract
  • Rosenman, SJ; Ganji, AA; Tedder, TF; Gallatin, WM. Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells. Journal of leukocyte biology. 1993;53:1-10.  Abstract
  • Strubel, NA; Nguyen, M; Kansas, GS; Tedder, TF; Bischoff, J. Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin. Biochemical and Biophysical Research Communications. 1993;192:338-344.  Abstract
  • Tedder, TF; Luscinskas, W; Kansas, GS. Regulation of leukocyte migration by L-selectin: mechanisms, domains and ligands. Behring Institute Mitteilungen. 1993;165-177.  Abstract
  • Wagner, N; Engel, P; Tedder, TF. Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45. Journal of immunology (Baltimore, Md. : 1950). 1993;150:4887-4899.  Abstract
  • Bast, BJ; Zhou, LJ; Freeman, GJ; Colley, KJ; Ernst, TJ; Munro, JM; Tedder, TF. The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. The Journal of Cell Biology. 1992;116:423-435.  Abstract
  • Birkenbach, M; Tong, X; Bradbury, LE; Tedder, TF; Kieff, E. Characterization of an Epstein-Barr virus receptor on human epithelial cells. The Journal of Experimental Medicine. 1992;176:1405-1414.  Abstract
  • Bradbury, LE; Kansas, GS; Levy, S; Evans, RL; Tedder, TF. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. Journal of immunology (Baltimore, Md. : 1950). 1992;149:2841-2850.  Abstract
  • Brady, HR; Spertini, O; Jimenez, W; Brenner, BM; Marsden, PA; Tedder, TF. Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro. Journal of immunology (Baltimore, Md. : 1950). 1992;149:2437-2444.  Abstract
  • Kansas, GS; Cambier, JC; Tedder, TF. CD4 binding to major histocompatibility complex class II antigens induces LFA-1-dependent and -independent homotypic adhesion of B lymphocytes. European Journal of Immunology. 1992;22:147-152.  Abstract
  • Mackay, CR; Marston, WL; Dudler, L; Spertini, O; Tedder, TF; Hein, WR. Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. European Journal of Immunology. 1992;22:887-895.  Abstract
  • Munro, S; Bast, BJ; Colley, KJ; Tedder, TF. The B lymphocyte surface antigen CD75 is not an alpha-2,6-sialyltransferase but is a carbohydrate antigen, the production of which requires the enzyme. Cell. 1992;68:1003.  Abstract
  • Schleiffenbaum, B; Spertini, O; Tedder, TF. Soluble L-selectin is present in human plasma at high levels and retains functional activity. The Journal of Cell Biology. 1992;119:229-238.  Abstract
  • Spertini, O; Luscinskas, FW; Gimbrone, MA; Tedder, TF. Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. The Journal of Experimental Medicine. 1992;175:1789-1792.  Abstract
  • Spertini, O; Schleiffenbaum, B; White-Owen, C; Ruiz, P; Tedder, TF. ELISA for quantitation of L-selectin shed from leukocytes in vivo. Journal of Immunological Methods. 1992;156:115-123.  Abstract
  • Zhou, LJ; Ord, DC; Omori, SA; Tedder, TF. Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. Immunogenetics. 1992;35:102-111.  Abstract
  • Zhou, LJ; Schwarting, R; Smith, HM; Tedder, TF. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. Journal of immunology (Baltimore, Md. : 1950). 1992;149:735-742.  Abstract
  • Kansas, GS; Spertini, O; Stoolman, LM; Tedder, TF. Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. The Journal of Cell Biology. 1991;114:351-358.  Abstract
  • Kansas, GS; Tedder, TF. Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. Journal of immunology (Baltimore, Md. : 1950). 1991;147:4094-4102.  Abstract
  • Kansas, GS; Wood, GS; Tedder, TF. Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1991;146:2235-2244.  Abstract
  • Matsumoto, AK; Kopicky-Burd, J; Carter, RH; Tuveson, DA; Tedder, TF; Fearon, DT. Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19. The Journal of Experimental Medicine. 1991;173:55-64.  Abstract
  • Spertini, O; Freedman, AS; Belvin, MP; Penta, AC; Griffin, JD; Tedder, TF. Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. Leukemia. 1991;5:300-308.  Abstract
  • Spertini, O; Kansas, GS; Munro, JM; Griffin, JD; Tedder, TF. Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Nature. 1991;349:691-694.  Abstract
  • Spertini, O; Kansas, GS; Reimann, KA; Mackay, CR; Tedder, TF. Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration. Journal of immunology (Baltimore, Md. : 1950). 1991;147:942-949.  Abstract
  • Spertini, O; Luscinskas, FW; Kansas, GS; Munro, JM; Griffin, JD; Gimbrone, MA; Tedder, TF. Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. Journal of immunology (Baltimore, Md. : 1950). 1991;147:2565-2573.  Abstract
  • Tedder, TF. Cell-surface receptor shedding: a means of regulating function. American journal of respiratory cell and molecular biology. 1991;5:305-306.  Abstract
  • Zhou, LJ; Ord, DC; Hughes, AL; Tedder, TF. Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. Journal of immunology (Baltimore, Md. : 1950). 1991;147:1424-1432.  Abstract
  • Charmley, P; Nguyen, J; Tedder, TF; Gatti, RA. A frequent human CD20 (B1) differentiation antigen DNA polymorphism detected with MspI is located near 11q12-13. Nucleic Acids Research. 1990;18:207.  Abstract
  • Griffin, JD; Spertini, O; Ernst, TJ; Belvin, MP; Levine, HB; Kanakura, Y; Tedder, TF. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. Journal of immunology (Baltimore, Md. : 1950). 1990;145:576-584.  Abstract
  • Ord, DC; Ernst, TJ; Zhou, LJ; Rambaldi, A; Spertini, O; Griffin, J; Tedder, TF. Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. The Journal of biological chemistry. 1990;265:7760-7767.  Abstract
  • Sleasman, JW; Morimoto, C; Schlossman, SF; Tedder, TF. The role of functionally distinct helper T lymphocyte subpopulations in the induction of human B cell differentiation. European Journal of Immunology. 1990;20:1357-1366.  Abstract
  • Sleasman, JW; Tedder, TF; Barrett, DJ. Combined immunodeficiency due to the selective absence of CD4 inducer T lymphocytes. Clinical Immunology and Immunopathology. 1990;55:401-417.  Abstract
  • Tedder, TF; Matsuyama, T; Rothstein, D; Schlossman, SF; Morimoto, C. Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation. European Journal of Immunology. 1990;20:1351-1355.  Abstract
  • Tedder, TF; Penta, AC; Levine, HB; Freedman, AS. Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. Journal of immunology (Baltimore, Md. : 1950). 1990;144:532-540.  Abstract
  • Watkins, DI; Chen, ZW; Hughes, AL; Evans, MG; Tedder, TF; Letvin, NL. Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Nature. 1990;346:60-63.  Abstract
  • Watkins, DI; Letvin, NL; Hughes, AL; Tedder, TF. Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells. Journal of immunology (Baltimore, Md. : 1950). 1990;144:1136-1143.  Abstract
  • Takeuchi, T; Rudd, CE; Tedder, TF; Schlossman, SF; Morimoto, C. Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen. Cellular Immunology. 1989;118:68-84.  Abstract
  • Tedder, TF; Disteche, CM; Louie, E; Adler, DA; Croce, CM; Schlossman, SF; Saito, H. The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site. Journal of immunology (Baltimore, Md. : 1950). 1989;142:2555-2559.  Abstract
  • Tedder, TF; Isaacs, CM. Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. Journal of immunology (Baltimore, Md. : 1950). 1989;143:712-717.  Abstract
  • Tedder, TF; Isaacs, CM; Ernst, TJ; Demetri, GD; Adler, DA; Disteche, CM. Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. The Journal of Experimental Medicine. 1989;170:123-133.  Abstract
  • Tedder, TF; Klejman, G; Schlossman, SF; Saito, H. Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1). Journal of immunology (Baltimore, Md. : 1950). 1989;142:2560-2568.  Abstract
  • Forsgren, A; Penta, A; Schlossman, SF; Tedder, TF. Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. Cellular Immunology. 1988;112:78-88.  Abstract
  • Tedder, TF; Klejman, G; Disteche, CM; Adler, DA; Schlossman, SF; Saito, H. Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19. Journal of immunology (Baltimore, Md. : 1950). 1988;141:4388-4394.  Abstract
  • Tedder, TF; McIntyre, G; Schlossman, SF. Heterogeneity in the B1 (CD20) cell surface molecule expressed by human B-lymphocytes. Molecular Immunology. 1988;25:1321-1330.  Abstract
  • Tedder, TF; Schlossman, SF. Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. The Journal of biological chemistry. 1988;263:10009-10015.  Abstract
  • Tedder, TF; Streuli, M; Schlossman, SF; Saito, H. Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proceedings of the National Academy of Sciences of USA. 1988;85:208-212.  Abstract
  • Boyd, AW; Tedder, TF; Griffin, JD; Freedman, AS; Fisher, DC; Daley, J; Nadler, LM. Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals. Cellular Immunology. 1987;106:355-365.  Abstract
  • Forsgren, A; Bredberg, A; Pardee, AB; Schlossman, SF; Tedder, TF. Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth. Antimicrobial agents and chemotherapy. 1987;31:774-779.  Abstract
  • Forsgren, A; Schlossman, SF; Tedder, TF. 4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro. Antimicrobial agents and chemotherapy. 1987;31:768-773.  Abstract
  • Lokhorst, HM; Boom, SE; Bast, BJ; Peters, PJ; Tedder, TF; Gerdes, J; Petersen, E; Ballieux, RE. Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern. Journal of Clinical Investigation. 1987;79:1401-1411.  Abstract
  • Sixbey, JW; Davis, DS; Young, LS; Hutt-Fletcher, L; Tedder, TF; Rickinson, AB. Human epithelial cell expression of an Epstein-Barr virus receptor. The Journal of general virology. 1987;68 ( Pt 3):805-811.  Abstract
  • Clement, LT; Tedder, TF; Gartland, GL. Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation. Journal of immunology (Baltimore, Md. : 1950). 1986;136:2375-2381.  Abstract
  • Tedder, TF; Forsgren, A; Boyd, AW; Nadler, LM; Schlossman, SF. Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. European Journal of Immunology. 1986;16:881-887.  Abstract
  • Tedder, TF; Goldmacher, VS; Lambert, JM; Schlossman, SF. Epstein Barr virus binding induces internalization of the C3d receptor: a novel immunotoxin delivery system. Journal of immunology (Baltimore, Md. : 1950). 1986;137:1387-1391.  Abstract
  • Tedder, TF; Schmidt, RE; Rudd, CE; Kornacki, MM; Ritz, J; Schlossman, SF. Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes. European Journal of Immunology. 1986;16:1539-1543.  Abstract
  • Tedder, TF; Weis, JJ; Clement, LT; Fearon, DT; Cooper, MD. The role of receptors for complement in the induction of polyclonal B-cell proliferation and differentiation. Journal of Clinical Immunology. 1986;6:65-73.  Abstract
  • Tedder, TF; Boyd, AW; Freedman, AS; Nadler, LM; Schlossman, SF. The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. Journal of immunology (Baltimore, Md. : 1950). 1985;135:973-979.  Abstract
  • Tedder, TF; Clement, LT; Cooper, MD. Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody. Journal of immunology (Baltimore, Md. : 1950). 1985;134:1539-1544.  Abstract
  • Tedder, TF; Clement, LT; Cooper, MD. Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression. Journal of immunology (Baltimore, Md. : 1950). 1985;134:2983-2988.  Abstract
  • Tedder, TF; Cooper, MD; Clement, LT. Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations. Journal of immunology (Baltimore, Md. : 1950). 1985;134:2989-2994.  Abstract
  • Tedder, TF; Crain, MJ; Kubagawa, H; Clement, LT; Cooper, MD. Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases. Journal of immunology (Baltimore, Md. : 1950). 1985;135:1786-1791.  Abstract
  • Calvert, JE; Maruyama, S; Tedder, TF; Webb, CF; Cooper, MD. Cellular events in the differentiation of antibody-secreting cells. Seminars in Hematology. 1984;21:226-243.  Abstract
  • Fingeroth, JD; Weis, JJ; Tedder, TF; Strominger, JL; Biro, PA; Fearon, DT. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proceedings of the National Academy of Sciences of USA. 1984;81:4510-4514.  Abstract
  • Tedder, TF; Clement, LT; Cooper, MD. Discontinuous expression of a membrane antigen (HB-7) during B lymphocyte differentiation. Tissue Antigens. 1984;24:140-149.  Abstract
  • Tedder, TF; Clement, LT; Cooper, MD. Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. Journal of immunology (Baltimore, Md. : 1950). 1984;133:678-683.  Abstract
  • Weis, JJ; Tedder, TF; Fearon, DT. Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes. Proceedings of the National Academy of Sciences of USA. 1984;81:881-885.  Abstract
  • Tedder, TF; Fearon, DT; Gartland, GL; Cooper, MD. Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells. Journal of immunology (Baltimore, Md. : 1950). 1983;130:1668-1673.  Abstract
  • Wilson, JG; Tedder, TF; Fearon, DT. Characterization of human T lymphocytes that express the C3b receptor. Journal of immunology (Baltimore, Md. : 1950). 1983;131:684-689.  Abstract
  • Eaton, LC; Tedder, TF; Ingram, LO. Effects of fatty acid composition on the sensitivity of membrane functions to ethanol in Escherichia coli. Substance and alcohol actions/misuse. 1982;3:77-87.  Abstract
  • Ingram, LO; Eaton, LC; Erdos, GW; Tedder, TF; Vreeland, NL. Unsaturated fatty acid requirement in Escherichia coli: mechanism of palmitate-induced inhibition of growth of strain WN1. The Journal of Membrane Biology. 1982;65:31-40.  Abstract
  • Tedder, TF; Hoffmann, EM. Immunoradiometric assay for examination and quantitation of Brucella abortus-specific antibodies reactive with the antigen(s) used in the indirect hemolysis test. Journal of clinical microbiology. 1981;14:415-426.  Abstract
  • Hoffmann, EM; Deyoe, BL; Nicoletti, PL; Tedder, TF. Conditions for conducting the indirect hemolysis test for detection of antibodies to Brucella abortus. Journal of clinical microbiology. 1980;11:402-408.  Abstract