Garnett H. Kelsoe, DSc, MS, MS

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Professor of Immunology
Department:
Immunology
Address:
117 Jones Bldg
207 Research Drive
Durham, NC 27710
Office Telephone:
(919) 613-7815
Training:
  • DSc, Harvard University, 1979
  • MS, Southern Methodist University, 1974
  • MS, Harvard University, 1975
Research Interests:
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerace. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in normal lymphocyte development and lymphoid malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to HIV-1.
Representative Publications:
  • Cain, DW; Snowden, PB; Sempowski, GD; Kelsoe, G. Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism. PLoS One. 2011;6:e19957.  Abstract
  • Kuraoka, M; Holl, TM; Liao, D; Womble, M; Cain, DW; Reynolds, AE; Kelsoe, G. Activation-induced cytidine deaminase mediates central tolerance in B cells. Proceedings of the National Academy of Sciences of USA. 2011;108:11560-11565.  Abstract
  • Kuraoka, M; Holl, TM; Liao, D; Womble, M; Cain, DW; Reynolds, AE; Kelsoe, G. Activation-induced cytidine deaminase mediates central tolerance in B cells. Proceedings of the National Academy of Sciences of USA. 2011;108:11560-11565.  Abstract
  • Verkoczy, L; Chen, Y; Bouton-Verville, H; Zhang, J; Diaz, M; Hutchinson, J; Ouyang, YB; Alam, SM; Holl, TM; Hwang, KK; Kelsoe, G; Haynes, BF. Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls. Journal of Immunology. 2011;187:3785-3797.  Abstract
  • Verkoczy, L; Chen, Y; Bouton-Verville, H; Zhang, J; Diaz, M; Hutchinson, J; Ouyang, YB; Alam, SM; Holl, TM; Hwang, KK; Kelsoe, G; Haynes, BF. Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls. Journal of Immunology. 2011;187:3785-3797.  Abstract
  • Verkoczy, L; Kelsoe, G; Moody, MA; Haynes, BF. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Current Opinion in Immunology. 2011;23:383-390.  Abstract
  • Holl, TM; Haynes, BF; Kelsoe, G. Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. Journal of Immunological Methods. 2010;354:53-67.  Abstract
  • Holl, TM; Haynes, BF; Kelsoe, G. Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. Journal of Immunological Methods. 2010;354:53-67.  Abstract
  • Nicely, NI; Dennison, SM; Spicer, L; Scearce, RM; Kelsoe, G; Ueda, Y; Chen, H; Liao, HX; Alam, SM; Haynes, BF. Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region. Nature Structural and Molecular Biology. 2010;17:1492-1494.  Abstract
  • Verkoczy, L; Diaz, M; Holl, TM; Ouyang, YB; Bouton-Verville, H; Alam, SM; Liao, HX; Kelsoe, G; Haynes, BF. Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proceedings of the National Academy of Sciences of USA. 2010;107:181-186.  Abstract
  • Kuraoka, M; Liao, D; Yang, K; Allgood, SD; Levesque, MC; Kelsoe, G; Ueda, Y. Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. Journal of Immunology. 2009;183:3237-3248.  Abstract
  • Ueda, Y; Cain, DW; Kuraoka, M; Kondo, M; Kelsoe, G. IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. Journal of Immunology. 2009;182:6477-6484.  Abstract
  • DiLillo, DJ; Hamaguchi, Y; Ueda, Y; Yang, K; Uchida, J; Haas, KM; Kelsoe, G; Tedder, TF. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. Journal of Immunology. 2008;180:361-371.  Abstract
  • Davila, M; Liu, F; Cowell, LG; Lieberman, AE; Heikamp, E; Patel, A; Kelsoe, G. Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. Journal of Experimental Medicine. 2007;204:3195-3208.  Abstract
  • Davila, M; Liu, F; Cowell, LG; Lieberman, AE; Heikamp, E; Patel, A; Kelsoe, G. Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. Journal of Experimental Medicine. 2007;204:3195-3208.  Abstract
  • Ueda, Y; Liao, D; Yang, K; Patel, A; Kelsoe, G. T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. Journal of Immunology. 2007;178:3593-3601.  Abstract
  • Holl, TM; Kelsoe, G. Outside influence: TLRs direct hematopoietic cell fates. Immunity. 2006;24:667-669.  Abstract
  • Ueda, Y; Kondo, M; Kelsoe, G. Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. Journal of Experimental Medicine. 2005;201:1771-1780.  Abstract
  • Ueda, Y; Yang, K; Foster, SJ; Kondo, M; Kelsoe, G. Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. Journal of Experimental Medicine. 2004;199:47-58.  Abstract
  • Cowell, LG; Davila, M; Yang, K; Kepler, TB; Kelsoe, G. Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling. Journal of Experimental Medicine. 2003;197:207-220.  Abstract
  • Dal Porto, JM; Haberman, AM; Kelsoe, G; Shlomchik, MJ. Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. Journal of Experimental Medicine. 2002;195:1215-1221.  Abstract
  • Davila, M; Foster, S; Kelsoe, G; Yang, K. A role for secondary V(D)J recombination in oncogenic chromosomal translocations?. Advances in Cancer Research. 2001;81:61-92.  Abstract
  • Davila, M; Foster, S; Kelsoe, G; Yang, K. A role for secondary V(D)J recombination in oncogenic chromosomal translocations?. Advances in Cancer Research. 2001;81:61-92.  Abstract
  • Chen, Z; Koralov, SB; Kelsoe, G. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. Journal of Experimental Medicine. 2000;192:1339-1352.  Abstract
  • Monroe, RJ; Seidl, KJ; Gaertner, F; Han, S; Chen, F; Sekiguchi, J; Wang, J; Ferrini, R; Davidson, L; Kelsoe, G; Alt, FW. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 1999;11:201-212.  Abstract
  • Monroe, RJ; Seidl, KJ; Gaertner, F; Han, S; Chen, F; Sekiguchi, J; Wang, J; Ferrini, R; Davidson, L; Kelsoe, G; Alt, FW. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 1999;11:201-212.  Abstract
  • Takahashi, Y; Dutta, PR; Cerasoli, DM; Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. Journal of Experimental Medicine. 1998;187:885-895.  Abstract
  • Takahashi, Y; Dutta, PR; Cerasoli, DM; Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. Journal of Experimental Medicine. 1998;187:885-895.  Abstract
  • Han, S; Dillon, SR; Zheng, B; Shimoda, M; Schlissel, MS; Kelsoe, G. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 1997;278:301-305.  Abstract
  • Han, S; Dillon, SR; Zheng, B; Shimoda, M; Schlissel, MS; Kelsoe, G. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 1997;278:301-305.  Abstract
  • Zheng, B; Han, S; Zhu, Q; Goldsby, R; Kelsoe, G. Alternative pathways for the selection of antigen-specific peripheral T cells. Nature. 1996;384:263-266.  Abstract
  • Han, S; Zheng, B; Dal Porto, J; Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. Journal of Experimental Medicine. 1995;182:1635-1644.  Abstract
  • Zheng, B; Xue, W; Kelsoe, G. Locus-specific somatic hypermutation in germinal centre T cells. Nature. 1994;372:556-559.  Abstract
  • Jacob, J; Przylepa, J; Miller, C; Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. Journal of Experimental Medicine. 1993;178:1293-1307.  Abstract
  • Jacob, J; Przylepa, J; Miller, C; Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. Journal of Experimental Medicine. 1993;178:1293-1307.  Abstract
  • Jacob, J; Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. Journal of Experimental Medicine. 1992;176:679-687.  Abstract
  • Jacob, J; Kelsoe, G; Rajewsky, K; Weiss, U. Intraclonal generation of antibody mutants in germinal centres. Nature. 1991;354:389-392.  Abstract
  • Kaushik, A; Schulze, DH; Bonilla, FA; Bona, C; Kelsoe, G. Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. Proceedings of the National Academy of Sciences of USA. 1990;87:4932-4936.  Abstract
  • Kaushik, A; Schulze, DH; Bonilla, FA; Bona, C; Kelsoe, G. Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. Proceedings of the National Academy of Sciences of USA. 1990;87:4932-4936.  Abstract
  • Kaushik, A; Schulze, DH; Bona, C; Kelsoe, G. Murine V kappa gene expression does not follow the VH paradigm. Journal of Experimental Medicine. 1989;169:1859-1864.  Abstract
  • Kaushik, A; Schulze, DH; Bona, C; Kelsoe, G. Murine V kappa gene expression does not follow the VH paradigm. Journal of Experimental Medicine. 1989;169:1859-1864.  Abstract
  • Schulze, DH; Kelsoe, G. Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. Journal of Experimental Medicine. 1987;166:163-172.  Abstract
  • Reth, M; Kelsoe, G; Rajewsky, K. Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. Nature. 1981;290:257-259.  Abstract
  • Reth, M; Kelsoe, G; Rajewsky, K. Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. Nature. 1981;290:257-259.  Abstract
  • Kelsoe, G; Isaak, D; Cerny, J. Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen. Journal of Experimental Medicine. 1980;151:289-300.  Abstract
  • Kelsoe, G; Isaak, D; Cerny, J. Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen. Journal of Experimental Medicine. 1980;151:289-300.  Abstract
  • Kelsoe, G; Cerny, J. Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation. Nature. 1979;279:333-334.  Abstract
  • Kelsoe, GH; Weller, TH. Immunodiagnosis of infection with Schistosoma mansoni: enzyme-linked immunosorbent assay for detection of antibody to circulating antigen. Proceedings of the National Academy of Sciences of USA. 1978;75:5715-5717.  Abstract
  • Kelsoe, GH; Weller, TH. Immunodiagnosis of infection with Schistosoma mansoni: enzyme-linked immunosorbent assay for detection of antibody to circulating antigen. Proceedings of the National Academy of Sciences of USA. 1978;75:5715-5717.  Abstract