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A Study by Dr. Soman Abraham Shows Why Exposure to Small Quantities of Allergens Can Suppress Allergic Responses

Monday, September 26, 2016
By Dr. Soman Abraham

It has been known for many years that controlled exposure to increasing doses of allergen can help individuals tolerate a subsequent exposure which would normally trigger a potent allergic response.  Dr. Abraham and colleagues have recently discovered the mechanism of this desensitization.  They found that controlled treatment with allergen causes a reorganization of the actin cytoskeleton in mast cells, which, in turn, interferes with the ability of mast cells to release mediators of the allergic response.  This new understanding could lead to the development of more effective therapies to suppress dangerous allergic reactions.

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