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Garnett H. Kelsoe, DSc

James B. Duke Distinguished Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • AssociateProfessor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University , 1979

Selected Grants and Awards

Selected Publications

Yang, Guang, T Matt Holl, Yang Liu, Yi Li, Xiaozhi Lu, Nathan I. Nicely, Thomas B. Kepler, et al. “Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.” J Exp Med 210, no. 2 (February 11, 2013): 241–56. https://doi.org/10.1084/jem.20121977.

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Haynes, Barton F., Garnett Kelsoe, Stephen C. Harrison, and Thomas B. Kepler. “B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study.” Nat Biotechnol 30, no. 5 (May 7, 2012): 423–33. https://doi.org/10.1038/nbt.2197.

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Liao, Hua-Xin, Xi Chen, Supriya Munshaw, Ruijun Zhang, Dawn J. Marshall, Nathan Vandergrift, John F. Whitesides, et al. “Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.” J Exp Med 208, no. 11 (October 24, 2011): 2237–49. https://doi.org/10.1084/jem.20110363.

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Verkoczy, Laurent, Yao Chen, Hilary Bouton-Verville, Jinsong Zhang, Marilyn Diaz, Jennifer Hutchinson, Ying-Bin Ouyang, et al. “Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls.” J Immunol 187, no. 7 (October 1, 2011): 3785–97. https://doi.org/10.4049/jimmunol.1101633.

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Kuraoka, Masayuki, T Matt Holl, Dongmei Liao, Mandy Womble, Derek W. Cain, Alexander E. Reynolds, and Garnett Kelsoe. “Activation-induced cytidine deaminase mediates central tolerance in B cells.” Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11560–65. https://doi.org/10.1073/pnas.1102571108.

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Verkoczy, Laurent, Garnett Kelsoe, M Anthony Moody, and Barton F. Haynes. “Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.” Curr Opin Immunol 23, no. 3 (June 2011): 383–90. https://doi.org/10.1016/j.coi.2011.04.003.

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Cain, Derek W., Pilar B. Snowden, Gregory D. Sempowski, and Garnett Kelsoe. “Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.” Plos One 6, no. 5 (2011): e19957. https://doi.org/10.1371/journal.pone.0019957.

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Nicely, Nathan I., S Moses Dennison, Leonard Spicer, Richard M. Scearce, Garnett Kelsoe, Yoshihiro Ueda, Haiyan Chen, Hua-Xin Liao, S Munir Alam, and Barton F. Haynes. “Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.” Nat Struct Mol Biol 17, no. 12 (December 2010): 1492–94. https://doi.org/10.1038/nsmb.1944.

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Holl, T Matt, Barton F. Haynes, and Garnett Kelsoe. “Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.” J Immunol Methods 354, no. 1–2 (March 31, 2010): 53–67. https://doi.org/10.1016/j.jim.2010.01.007.

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Verkoczy, Laurent, Marilyn Diaz, T Matt Holl, Ying-Bin Ouyang, Hilary Bouton-Verville, S Munir Alam, Hua-Xin Liao, Garnett Kelsoe, and Barton F. Haynes. “Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance.” Proc Natl Acad Sci U S A 107, no. 1 (January 5, 2010): 181–86. https://doi.org/10.1073/pnas.0912914107.

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Kuraoka, Masayuki, Dongmei Liao, Kaiyong Yang, Sallie D. Allgood, Marc C. Levesque, Garnett Kelsoe, and Yoshihiro Ueda. “Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.” J Immunol 183, no. 5 (September 1, 2009): 3237–48. https://doi.org/10.4049/jimmunol.0901548.

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Ueda, Yoshihiro, Derek W. Cain, Masayuki Kuraoka, Motonari Kondo, and Garnett Kelsoe. “IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.” J Immunol 182, no. 10 (May 15, 2009): 6477–84. https://doi.org/10.4049/jimmunol.0803961.

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DiLillo, David J., Yasuhito Hamaguchi, Yoshihiro Ueda, Kaiyong Yang, Junji Uchida, Karen M. Haas, Garnett Kelsoe, and Thomas F. Tedder. “Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice.” J Immunol 180, no. 1 (January 1, 2008): 361–71. https://doi.org/10.4049/jimmunol.180.1.361.

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Davila, Marco, Feifei Liu, Lindsay G. Cowell, Anne E. Lieberman, Emily Heikamp, Anjali Patel, and Garnett Kelsoe. “Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells.” J Exp Med 204, no. 13 (December 24, 2007): 3195–3208. https://doi.org/10.1084/jem.20071224.

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Ueda, Yoshihiro, Dongmei Liao, Kaiyong Yang, Anjali Patel, and Garnett Kelsoe. “T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.” J Immunol 178, no. 6 (March 15, 2007): 3593–3601. https://doi.org/10.4049/jimmunol.178.6.3593.

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