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Garnett H. Kelsoe, DSc

James B. Duke Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • Associate Professor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University, 1979

Selected Publications

Holl, TM, Haynes, BF, and Kelsoe, G. "Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones." J Immunol Methods 354, no. 1-2 (March 31, 2010): 53-67.

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Verkoczy, L, Diaz, M, Holl, TM, Ouyang, Y-B, Bouton-Verville, H, Alam, SM, Liao, H-X, Kelsoe, G, and Haynes, BF. "Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance." Proc Natl Acad Sci U S A 107, no. 1 (January 5, 2010): 181-186.

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Kuraoka, Masayuki, Dongmei Liao, Kaiyong Yang, Sallie D. Allgood, Marc C. Levesque, Garnett Kelsoe, and Yoshihiro Ueda. “Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome..” J Immunol 183, no. 5 (September 1, 2009): 3237–48. https://doi.org/10.4049/jimmunol.0901548.

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Ueda, Y, Cain, DW, Kuraoka, M, Kondo, M, and Kelsoe, G. "IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia." J Immunol 182, no. 10 (May 15, 2009): 6477-6484.

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DiLillo, DJ, Hamaguchi, Y, Ueda, Y, Yang, K, Uchida, J, Haas, KM, Kelsoe, G, and Tedder, TF. "Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice." J Immunol 180, no. 1 (January 1, 2008): 361-371.

Scholars@Duke

Davila, M, Liu, F, Cowell, LG, Lieberman, AE, Heikamp, E, Patel, A, and Kelsoe, G. "Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells." J Exp Med 204, no. 13 (December 24, 2007): 3195-3208.

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Ueda, Y, Liao, D, Yang, K, Patel, A, and Kelsoe, G. "T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells." J Immunol 178, no. 6 (March 15, 2007): 3593-3601.

Scholars@Duke

Ueda, Y, Kondo, M, and Kelsoe, G. "Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow." J Exp Med 201, no. 11 (June 6, 2005): 1771-1780.

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Haynes, BF, Moody, MA, Verkoczy, L, Kelsoe, G, and Alam, SM. "Antibody polyspecificity and neutralization of HIV-1: a hypothesis." Hum Antibodies 14, no. 3-4 (2005): 59-67. (Review)

Scholars@Duke

Ueda, Y, Yang, K, Foster, SJ, Kondo, M, and Kelsoe, G. "Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression." J Exp Med 199, no. 1 (January 5, 2004): 47-58.

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Lee, AI, Fugmann, SD, Cowell, LG, Ptaszek, LM, Kelsoe, G, and Schatz, DG. "A functional analysis of the spacer of V(D)J recombination signal sequences." PLoS Biol 1, no. 1 (October 2003): E1-.

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Cowell, LG, Davila, M, Yang, K, Kepler, TB, and Kelsoe, G. "Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling." J Exp Med 197, no. 2 (January 20, 2003): 207-220.

Scholars@Duke

Liang, H-E, Hsu, L-Y, Cado, D, Cowell, LG, Kelsoe, G, and Schlissel, MS. "The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development." Immunity 17, no. 5 (November 2002): 639-651.

Scholars@Duke

Dal Porto, JM, Haberman, AM, Kelsoe, G, and Shlomchik, MJ. "Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced." J Exp Med 195, no. 9 (May 6, 2002): 1215-1221.

Scholars@Duke

Cowell, LG, Davila, M, Kepler, TB, and Kelsoe, G. "Identification and utilization of arbitrary correlations in models of recombination signal sequences." Genome Biol 3, no. 12 (2002): RESEARCH0072-.

Scholars@Duke

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