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Garnett H. Kelsoe, DSc

James B. Duke Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • Associate Professor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University, 1979

Selected Publications

Luzina, IG, Atamas, SP, Storrer, CE, daSilva, LC, Kelsoe, G, Papadimitriou, JC, and Handwerger, BS. "Spontaneous formation of germinal centers in autoimmune mice." J Leukoc Biol 70, no. 4 (October 2001): 578-584.

Scholars@Duke

Davila, M, Foster, S, Kelsoe, G, and Yang, K. "A role for secondary V(D)J recombination in oncogenic chromosomal translocations?." Adv Cancer Res 81 (2001): 61-92. (Review)

Scholars@Duke

Chen, Z, Koralov, SB, and Kelsoe, G. "Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2." J Exp Med 192, no. 9 (November 6, 2000): 1339-1352.

Scholars@Duke

Takahashi, Y, Cerasoli, DM, Dal Porto, JM, Shimoda, M, Freund, R, Fang, W, Telander, DG, Malvey, EN, Mueller, DL, Behrens, TW, and Kelsoe, G. "Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice." J Exp Med 190, no. 3 (August 2, 1999): 399-410.

Scholars@Duke

Monroe, RJ, Seidl, KJ, Gaertner, F, Han, S, Chen, F, Sekiguchi, J, Wang, J, Ferrini, R, Davidson, L, Kelsoe, G, and Alt, FW. "RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues." Immunity 11, no. 2 (August 1999): 201-212.

Scholars@Duke

Dal Porto, JM, Haberman, AM, Shlomchik, MJ, and Kelsoe, G. "Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers." J Immunol 161, no. 10 (November 15, 1998): 5373-5381.

Scholars@Duke

Takahashi, Y, Dutta, PR, Cerasoli, DM, and Kelsoe, G. "In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection." J Exp Med 187, no. 6 (March 16, 1998): 885-895.

Scholars@Duke

Han, S, Dillon, SR, Zheng, B, Shimoda, M, Schlissel, MS, and Kelsoe, G. "V(D)J recombinase activity in a subset of germinal center B lymphocytes." Science 278, no. 5336 (October 10, 1997): 301-305.

Scholars@Duke

Zheng, B, Han, S, Zhu, Q, Goldsby, R, and Kelsoe, G. "Alternative pathways for the selection of antigen-specific peripheral T cells." Nature 384, no. 6606 (November 21, 1996): 263-266.

Full Text

Han, S, Zheng, B, Dal Porto, J, and Kelsoe, G. "In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance." J Exp Med 182, no. 6 (December 1, 1995): 1635-1644.

Scholars@Duke

Zheng, B, Xue, W, and Kelsoe, G. "Locus-specific somatic hypermutation in germinal centre T cells." Nature 372, no. 6506 (December 8, 1994): 556-559.

Full Text

Jacob, J, Przylepa, J, Miller, C, and Kelsoe, G. "In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells." J Exp Med 178, no. 4 (October 1, 1993): 1293-1307.

Scholars@Duke

Jacob, J, and Kelsoe, G. "In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers." J Exp Med 176, no. 3 (September 1, 1992): 679-687.

Scholars@Duke

Jacob, J, Kelsoe, G, Rajewsky, K, and Weiss, U. "Intraclonal generation of antibody mutants in germinal centres." Nature 354, no. 6352 (December 5, 1991): 389-392.

Full Text

Jacob, J, Kassir, R, and Kelsoe, G. "In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations." J Exp Med 173, no. 5 (May 1, 1991): 1165-1175.

Scholars@Duke

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