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Garnett H. Kelsoe, DSc

James B. Duke Distinguished Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • AssociateProfessor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University , 1979

Selected Grants and Awards

Selected Publications

Ueda, Yoshihiro, Motonari Kondo, and Garnett Kelsoe. “Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.” J Exp Med 201, no. 11 (June 6, 2005): 1771–80. https://doi.org/10.1084/jem.20041419.

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Haynes, Barton F., M Anthony Moody, Laurent Verkoczy, Garnett Kelsoe, and S Munir Alam. “Antibody polyspecificity and neutralization of HIV-1: a hypothesis.” Hum Antibodies 14, no. 3–4 (2005): 59–67.

Scholars@Duke

Ueda, Yoshihiro, Kaiyong Yang, Sandra J. Foster, Motonari Kondo, and Garnett Kelsoe. “Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.” J Exp Med 199, no. 1 (January 5, 2004): 47–58. https://doi.org/10.1084/jem.20031104.

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Lee, Alfred Ian, Sebastian D. Fugmann, Lindsay G. Cowell, Leon M. Ptaszek, Garnett Kelsoe, and David G. Schatz. “A functional analysis of the spacer of V(D)J recombination signal sequences.” Plos Biol 1, no. 1 (October 2003): E1. https://doi.org/10.1371/journal.pbio.0000001.

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Cowell, Lindsay G., Marco Davila, Kaiyong Yang, Thomas B. Kepler, and Garnett Kelsoe. “Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling.” J Exp Med 197, no. 2 (January 20, 2003): 207–20. https://doi.org/10.1084/jem.20020250.

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Liang, Hong-Erh, Lih-Yun Hsu, Dragana Cado, Lindsay G. Cowell, Garnett Kelsoe, and Mark S. Schlissel. “The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development.” Immunity 17, no. 5 (November 2002): 639–51. https://doi.org/10.1016/s1074-7613(02)00448-x.

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Dal Porto, Joseph M., Ann M. Haberman, Garnett Kelsoe, and Mark J. Shlomchik. “Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced.” J Exp Med 195, no. 9 (May 6, 2002): 1215–21. https://doi.org/10.1084/jem.20011550.

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Luzina, I. G., S. P. Atamas, C. E. Storrer, L. C. daSilva, G. Kelsoe, J. C. Papadimitriou, and B. S. Handwerger. “Spontaneous formation of germinal centers in autoimmune mice.” J Leukoc Biol 70, no. 4 (October 2001): 578–84.

Scholars@Duke

Davila, M., S. Foster, G. Kelsoe, and K. Yang. “A role for secondary V(D)J recombination in oncogenic chromosomal translocations?” Adv Cancer Res 81 (2001): 61–92. https://doi.org/10.1016/s0065-230x(01)81002-2.

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Chen, Z., S. B. Koralov, and G. Kelsoe. “Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.” J Exp Med 192, no. 9 (November 6, 2000): 1339–52. https://doi.org/10.1084/jem.192.9.1339.

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Takahashi, Y., D. M. Cerasoli, J. M. Dal Porto, M. Shimoda, R. Freund, W. Fang, D. G. Telander, et al. “Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice.” J Exp Med 190, no. 3 (August 2, 1999): 399–410. https://doi.org/10.1084/jem.190.3.399.

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Monroe, R. J., K. J. Seidl, F. Gaertner, S. Han, F. Chen, J. Sekiguchi, J. Wang, et al. “RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.” Immunity 11, no. 2 (August 1999): 201–12. https://doi.org/10.1016/s1074-7613(00)80095-3.

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Dal Porto, J. M., A. M. Haberman, M. J. Shlomchik, and G. Kelsoe. “Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers.” J Immunol 161, no. 10 (November 15, 1998): 5373–81.

Scholars@Duke

Takahashi, Y., P. R. Dutta, D. M. Cerasoli, and G. Kelsoe. “In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.” J Exp Med 187, no. 6 (March 16, 1998): 885–95. https://doi.org/10.1084/jem.187.6.885.

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