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Garnett H. Kelsoe, DSc

James B. Duke Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • Associate Professor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University, 1979

Selected Publications

Kaushik, A, Schulze, DH, Bonilla, FA, Bona, C, and Kelsoe, G. "Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells." Proc Natl Acad Sci U S A 87, no. 13 (July 1990): 4932-4936.

Scholars@Duke

Kaushik, A, Schulze, DH, Bona, C, and Kelsoe, G. "Murine V kappa gene expression does not follow the VH paradigm." J Exp Med 169, no. 5 (May 1, 1989): 1859-1864.

Scholars@Duke

Schulze, DH, and Kelsoe, G. "Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice." J Exp Med 166, no. 1 (July 1, 1987): 163-172.

Scholars@Duke

Kelsoe, G. "Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies." Methods Enzymol 150 (1987): 287-304.

Scholars@Duke

Reth, M, Kelsoe, G, and Rajewsky, K. "Idiotypic regulation by isologous monoclonal anti-idiotope antibodies." Nature 290, no. 5803 (March 19, 1981): 257-259.

Scholars@Duke

Kelsoe, G, Isaak, D, and Cerny, J. "Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen." J Exp Med 151, no. 2 (February 1, 1980): 289-300.

Scholars@Duke

Kelsoe, G, and Cerny, J. "Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation." Nature 279, no. 5711 (May 24, 1979): 333-334.

Scholars@Duke

Kelsoe, GH, and Weller, TH. "Immunodiagnosis of infection with Schistosoma mansoni: enzyme-linked immunosorbent assay for detection of antibody to circulating antigen." Proc Natl Acad Sci U S A 75, no. 11 (November 1978): 5715-5717.

Scholars@Duke

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