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Garnett H. Kelsoe, DSc

James B. Duke Distinguished Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • AssociateProfessor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University , 1979

Selected Grants and Awards

Selected Publications

Zheng, B., S. Han, Q. Zhu, R. Goldsby, and G. Kelsoe. “Alternative pathways for the selection of antigen-specific peripheral T cells.” Nature 384, no. 6606 (November 21, 1996): 263–66. https://doi.org/10.1038/384263a0.

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Han, S., B. Zheng, J. Dal Porto, and G. Kelsoe. “In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.” J Exp Med 182, no. 6 (December 1, 1995): 1635–44. https://doi.org/10.1084/jem.182.6.1635.

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Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. “In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.” J Exp Med 178, no. 4 (October 1, 1993): 1293–1307. https://doi.org/10.1084/jem.178.4.1293.

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Jacob, J., and G. Kelsoe. “In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.” J Exp Med 176, no. 3 (September 1, 1992): 679–87. https://doi.org/10.1084/jem.176.3.679.

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Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. “Intraclonal generation of antibody mutants in germinal centres.” Nature 354, no. 6352 (December 5, 1991): 389–92. https://doi.org/10.1038/354389a0.

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Jacob, J., R. Kassir, and G. Kelsoe. “In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.” J Exp Med 173, no. 5 (May 1, 1991): 1165–75. https://doi.org/10.1084/jem.173.5.1165.

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Kaushik, A., D. H. Schulze, F. A. Bonilla, C. Bona, and G. Kelsoe. “Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.” Proc Natl Acad Sci U S A 87, no. 13 (July 1990): 4932–36. https://doi.org/10.1073/pnas.87.13.4932.

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Schulze, D. H., and G. Kelsoe. “Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.” J Exp Med 166, no. 1 (July 1, 1987): 163–72. https://doi.org/10.1084/jem.166.1.163.

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Kelsoe, G. “Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies.” Methods Enzymol 150 (1987): 287–304. https://doi.org/10.1016/0076-6879(87)50086-6.

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Reth, M., G. Kelsoe, and K. Rajewsky. “Idiotypic regulation by isologous monoclonal anti-idiotope antibodies.” Nature 290, no. 5803 (March 19, 1981): 257–59. https://doi.org/10.1038/290257a0.

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Kelsoe, G., D. Isaak, and J. Cerny. “Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen.” J Exp Med 151, no. 2 (February 1, 1980): 289–300. https://doi.org/10.1084/jem.151.2.289.

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Kelsoe, G., and J. Cerny. “Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation.” Nature 279, no. 5711 (May 24, 1979): 333–34. https://doi.org/10.1038/279333a0.

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