Morse, MA, Nair, SK, Mosca, PJ, Hobeika, AC, Clay, TM, Deng, Y, Boczkowski, D, Proia, A, Neidzwiecki, D, Clavien, P-A, Hurwitz, HI, Schlom, J, Gilboa, E, and Lyerly, HK. "Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA." Cancer Invest 21, no. 3 (June 2003): 341-349.
Herbert Kim Lyerly, MD
George Barth Geller Professor
Campus Mail:
203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Phone:
(919) 681-8350
Email:
lyerl001@mc.duke.edu
Education and Training
- M.D., University of California at Los Angeles, 1983
Selected Grants and Awards
- Defining the Rules of Breast Cancer Cell Traffic Through Bone
- Translational Research in Surgical Oncology
- Transfusion Medicine and Hematology
- Astatine And Iodine Radiolabeled Monoclonal Antibodies
- Immunotherapeutic Targeting of a Therapy Resistant Oncogenic HER2 Isoform
- Labeling nanobodies with 18F residualizing labels for HER2 specific PET imaging
- A Molecular Framework for Understanding DCIS
- Viral Oncology Training Grant
- Mechanisms of Action and Resistance to PD-1 Immunotherapies in Breast Cancer
- Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy
- Oncogenic Signaling Networks
- Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy
- Duke University Program in Environmental Health
- A Cancer Rainbow Mouse for Simultaneous Assessment of Multiple Oncogenes
- AAADV Fundamentals
- Advancing Immunology in Dogs with Naturally-occurring Invasive Bladder Cancer, a Relevant Model to Improve Immunotherapy Across Molecular Cancer Subtypes in Humans
- A Simple System for Early Detection of Breast Cancer
- AAADV Scholars
- AAADV Scholars
- AAADV Scholars
- AAADV Workshop
- Cancer Biology Training Grant
- Integrating Population and Basic Science in Cancer Research
- Clinical Oncology Research Career Development Program
- 2015 Accelerating Anticancer Agent Development and Validation Workshop
- A Cancer Rainbow Mouse for the Simultaneous Assessment of Multiple Oncogenes
- Administrative Supplement for Recruitment of New Faculty
- Immunotherapy with High Frequency, CEA Specific
- SPORE in Breast Cancer
- Cancer Center Core Grant Supplement - Accelerating Anticancer Agent Dev Workshop
- Cancer Center Core Grant Supplement - Accelerating Anticancer Agent Dev Workshop
- Targeting hCG-beta for Breast Cancer Immunotherapy
- Developing Biomarker-Based Prognostics in Breast Cancer
- Vaccination with Regulatory T Cell Depletion
- Phase II trial of Cetuximab & Carboplatin in Basal-like Breast Cancer
- Markers of short term breast cancer risk in FNA
- Novel Biomarkers for Aromatase Inhibitor Therapy
- Biomarker Studies for Novel Anti-Cancer Agents
- Dendritic Cell Based Immunotherapy
- Immunotherapy using peptide MHC tetramer isolated Tcells
- Dendritic Cell Mobilization and Active Immunotherapy
- Immunologic Correlates of Effective Immunizations for Cancer Vaccines
- Planning a Duke Academic Public Private Partnership Program (AP4) Center
- Phase II Trial of Estradiol Therapy for Advanced Breast Cancer
- Mentored Oriented Research Career Development Award
- Cancer Center Core Grant - CURE Supplment
- Immunotherapy of Prostate Cancer with Tumor Vaccines
- RNA Transfected Dendritic Cells for Cancer Immunotherapy
- Dexasome Based Immunotherapy of Lung Cancer
- Immunotherapy with TRICOM Modified Dendritic Cells
- Cytomation MoFlo High Performance Flow Cytometer
- Dendritic Cell Immunotherapy For Breast Cancer
- Cancer Immunotherapy With Rna Pulsed Dendritic Cells
- Immunotherapy With Peptide Pulsed Dendritic Cell
- Immunotherapy With Peptide Pulsed Dendritic Cells
- Viral Control And Immune Reconstitution In Hiv Infection
- Viral Control & Immune Reconstitution In Hiv Infection
- Immunotherapy Of Breast Cance5 With Gene Modified Tumor
- Immunotherapy Of Breast Cancer With Gene Modified Tumor
- DUMC Aids Malignancy Program
- Dumc Aids Malignancy Program
- Spore In Breast Cancer
- Spore In Breast Cancer
- Surrogate Markers Of Tumor Specific Immunity
- Preclinical Development Of Rna Decoys
- Adoptive Immunotherapy For Aids Lymphoma
- Cellular Immunity Against Post-Transplant Lymphoma
Selected Publications
Lyerly, HK. "Quantitating cellular immune responses to cancer vaccines." Semin Oncol 30, no. 3 Suppl 8 (June 2003): 9-16. (Review)
Morse, MA, Clay, TM, Colling, K, Hobeika, A, Grabstein, K, Cheever, MA, and Lyerly, HK. "HER2 dendritic cell vaccines." Clin Breast Cancer 3 Suppl 4 (February 2003): S164-S172.
Mosca, PJ, Hobeika, AC, Colling, K, Clay, TM, Thomas, EK, Caron, D, Lyerly, HK, and Morse, MA. "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand." J Leukoc Biol 72, no. 3 (September 2002): 546-553.
Morse, MA, Rizzieri, D, Stenzel, TT, Hobeika, AC, Vredenburgh, JJ, Chao, NJ, Clay, TM, Mosca, PJ, and Lyerly, HK. "Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants." J Hematother Stem Cell Res 11, no. 4 (August 2002): 659-668.
Morse, MA, and Lyerly, HK. "DNA and RNA modified dendritic cell vaccines." World J Surg 26, no. 7 (July 2002): 819-825. (Review)
Clay, TM, Morse, M, and Lyerly, HK. "Redirecting cytotoxic T lymphocyte responses with T-cell receptor transgenes." Expert Opin Biol Ther 2, no. 4 (April 2002): 353-360. (Review)
Morse, MA, Clay, TM, and Lyerly, HK. "Current status of adoptive immunotherapy of malignancies." Expert Opin Biol Ther 2, no. 3 (March 2002): 237-247. (Review)
Keilholz, U, Weber, J, Finke, JH, Gabrilovich, DI, Kast, WM, Disis, ML, Kirkwood, JM, Scheibenbogen, C, Schlom, J, Maino, VC, Lyerly, HK, Lee, PP, Storkus, W, Marincola, F, Worobec, A, and Atkins, MB. "Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy." J Immunother 25, no. 2 (March 2002): 97-138. (Review)
Morse, MA, Nair, SK, Boczkowski, D, Tyler, D, Hurwitz, HI, Proia, A, Clay, TM, Schlom, J, Gilboa, E, and Lyerly, HK. "The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer." Int J Gastrointest Cancer 32, no. 1 (2002): 1-6.
Morse, MA, Nair, S, Fernandez-Casal, M, Deng, Y, St Peter, M, Williams, R, Hobeika, A, Mosca, P, Clay, T, Cumming, RI, Fisher, E, Clavien, P, Proia, AD, Niedzwiecki, D, Caron, D, and Lyerly, HK. "Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer." J Clin Oncol 18, no. 23 (December 1, 2000): 3883-3893.
Mosca, PJ, Hobeika, AC, Clay, TM, Nair, SK, Thomas, EK, Morse, MA, and Lyerly, HK. "A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment." Blood 96, no. 10 (November 15, 2000): 3499-3504.
Li, Y, Bendandi, M, Deng, Y, Dunbar, C, Munshi, N, Jagannath, S, Kwak, LW, and Lyerly, HK. "Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells." Blood 96, no. 8 (October 15, 2000): 2828-2833.
Lyerly, HK, Clay, T, and Morse, MA. "Optimizing dendritic cell function by genetic modification." J Natl Cancer Inst 92, no. 15 (August 2, 2000): 1198-1199.
Markert, ML, Hicks, CB, Bartlett, JA, Harmon, JL, Hale, LP, Greenberg, ML, Ferrari, G, Ottinger, J, Boeck, A, Kloster, AL, McLaughlin, TM, Bleich, KB, Ungerleider, RM, Lyerly, HK, Wilkinson, WE, Rousseau, FS, Heath-Chiozzi, ME, Leonard, JM, Haase, AT, Shaw, GM, Bucy, RP, Douek, DC, Koup, RA, Haynes, BF, Bolognesi, DP, and Weinhold, KJ. "Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection." AIDS Res Hum Retroviruses 16, no. 5 (March 20, 2000): 403-413.