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Herbert Kim Lyerly, MD

George Barth Geller Professor
Campus Mail: 203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Phone: (919) 681-8350
Email: lyerl001@mc.duke.edu

Education and Training

  • M.D., University of California at Los Angeles, 1983

Selected Grants and Awards

Selected Publications

Morse, MA, Nair, SK, Mosca, PJ, Hobeika, AC, Clay, TM, Deng, Y, Boczkowski, D, Proia, A, Neidzwiecki, D, Clavien, P-A, Hurwitz, HI, Schlom, J, Gilboa, E, and Lyerly, HK. "Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA." Cancer Invest 21, no. 3 (June 2003): 341-349.

Scholars@Duke

Lyerly, HK. "Quantitating cellular immune responses to cancer vaccines." Semin Oncol 30, no. 3 Suppl 8 (June 2003): 9-16. (Review)

Scholars@Duke

Morse, MA, Clay, TM, Colling, K, Hobeika, A, Grabstein, K, Cheever, MA, and Lyerly, HK. "HER2 dendritic cell vaccines." Clin Breast Cancer 3 Suppl 4 (February 2003): S164-S172.

Scholars@Duke

Mosca, PJ, Hobeika, AC, Colling, K, Clay, TM, Thomas, EK, Caron, D, Lyerly, HK, and Morse, MA. "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand." J Leukoc Biol 72, no. 3 (September 2002): 546-553.

Scholars@Duke

Morse, MA, Rizzieri, D, Stenzel, TT, Hobeika, AC, Vredenburgh, JJ, Chao, NJ, Clay, TM, Mosca, PJ, and Lyerly, HK. "Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants." J Hematother Stem Cell Res 11, no. 4 (August 2002): 659-668.

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Morse, MA, and Lyerly, HK. "DNA and RNA modified dendritic cell vaccines." World J Surg 26, no. 7 (July 2002): 819-825. (Review)

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Clay, TM, Morse, M, and Lyerly, HK. "Redirecting cytotoxic T lymphocyte responses with T-cell receptor transgenes." Expert Opin Biol Ther 2, no. 4 (April 2002): 353-360. (Review)

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Morse, MA, Clay, TM, and Lyerly, HK. "Current status of adoptive immunotherapy of malignancies." Expert Opin Biol Ther 2, no. 3 (March 2002): 237-247. (Review)

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Keilholz, U, Weber, J, Finke, JH, Gabrilovich, DI, Kast, WM, Disis, ML, Kirkwood, JM, Scheibenbogen, C, Schlom, J, Maino, VC, Lyerly, HK, Lee, PP, Storkus, W, Marincola, F, Worobec, A, and Atkins, MB. "Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy." J Immunother 25, no. 2 (March 2002): 97-138. (Review)

Scholars@Duke

Morse, MA, Nair, SK, Boczkowski, D, Tyler, D, Hurwitz, HI, Proia, A, Clay, TM, Schlom, J, Gilboa, E, and Lyerly, HK. "The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer." Int J Gastrointest Cancer 32, no. 1 (2002): 1-6.

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Morse, MA, Nair, S, Fernandez-Casal, M, Deng, Y, St Peter, M, Williams, R, Hobeika, A, Mosca, P, Clay, T, Cumming, RI, Fisher, E, Clavien, P, Proia, AD, Niedzwiecki, D, Caron, D, and Lyerly, HK. "Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer." J Clin Oncol 18, no. 23 (December 1, 2000): 3883-3893.

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Mosca, PJ, Hobeika, AC, Clay, TM, Nair, SK, Thomas, EK, Morse, MA, and Lyerly, HK. "A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment." Blood 96, no. 10 (November 15, 2000): 3499-3504.

Scholars@Duke

Li, Y, Bendandi, M, Deng, Y, Dunbar, C, Munshi, N, Jagannath, S, Kwak, LW, and Lyerly, HK. "Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells." Blood 96, no. 8 (October 15, 2000): 2828-2833.

Scholars@Duke

Lyerly, HK, Clay, T, and Morse, MA. "Optimizing dendritic cell function by genetic modification." J Natl Cancer Inst 92, no. 15 (August 2, 2000): 1198-1199.

Scholars@Duke

Markert, ML, Hicks, CB, Bartlett, JA, Harmon, JL, Hale, LP, Greenberg, ML, Ferrari, G, Ottinger, J, Boeck, A, Kloster, AL, McLaughlin, TM, Bleich, KB, Ungerleider, RM, Lyerly, HK, Wilkinson, WE, Rousseau, FS, Heath-Chiozzi, ME, Leonard, JM, Haase, AT, Shaw, GM, Bucy, RP, Douek, DC, Koup, RA, Haynes, BF, Bolognesi, DP, and Weinhold, KJ. "Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection." AIDS Res Hum Retroviruses 16, no. 5 (March 20, 2000): 403-413.

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