Sun, T, Han, H, Hudalla, GA, Wen, Y, Pompano, RR, and Collier, JH. "Thermal stability of self-assembled peptide vaccine materials." Acta biomaterialia 30 (January 2016): 62-71.
Joel Collier, PhD
The Collier Lab designs biomaterials for a range of biomedical applications, with a focus on understanding and controlling adaptive immune responses. Most materials investigated are created from molecular assemblies- proteins, peptides or bioconjugates that self-organize into useful structures such as nanofibers, gels, and particles.
These biomaterials are being developed as novel treatments for infectious diseases, cancer, wound healing, and chronic inflammation. Additionally, as these strategies are developed, basic insights into how materials engage the immune system are uncovered.
Education and Training
- Ph.D., Northwestern University, 2003
Selected Grants and Awards
- Supramolecular nanofiber vaccines
- Supramolecular matrix materials for prostate cancer cell biology
- Acquisition of a MALDI-TOF Mass Spectrometer System at Duke University
- Immunomodulatory Biomaterials via Peptide and Protein Self-Assembly
- Modular Biomaterials for Targeted Anti-Cytokine Immunotherapies
Wen, Y, and Collier, JH. "Supramolecular peptide vaccines: tuning adaptive immunity." Current opinion in immunology 35 (August 2015): 73-79. (Review)
Pompano, RR, Chen, J, Verbus, EA, Han, H, Fridman, A, McNeely, T, Collier, JH, and Chong, AS. "Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs." Advanced healthcare materials 3, no. 11 (November 2014): 1898-1908.
Hudalla, GA, Sun, T, Gasiorowski, JZ, Han, H, Tian, YF, Chong, AS, and Collier, JH. "Gradated assembly of multiple proteins into supramolecular nanomaterials." Nature materials 13, no. 8 (August 2014): 829-836.
Chen, J, Pompano, RR, Santiago, FW, Maillat, L, Sciammas, R, Sun, T, Han, H, Topham, DJ, Chong, AS, and Collier, JH. "The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation." Biomaterials 34, no. 34 (November 2013): 8776-8785.
Hudalla, GA, Modica, JA, Tian, YF, Rudra, JS, Chong, AS, Sun, T, Mrksich, M, and Collier, JH. "A self-adjuvanting supramolecular vaccine carrying a folded protein antigen." Advanced healthcare materials 2, no. 8 (August 2013): 1114-1119.
Jung, JP, Moyano, JV, and Collier, JH. "Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices." Integrative biology : quantitative biosciences from nano to macro 3, no. 3 (March 2011): 185-196.
Rudra, JS, Tian, YF, Jung, JP, and Collier, JH. "A self-assembling peptide acting as an immune adjuvant." Proceedings of the National Academy of Sciences of the United States of America 107, no. 2 (January 2010): 622-627.