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Jorn Coers, PhD

Selected Publications

Coers, J, Brown, HM, Hwang, S, and Taylor, GA. "Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense." Current Opinion in Immunology 54 (October 2018): 93-101. (Review)

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Liu, BC, Sarhan, J, Panda, A, Muendlein, HI, Ilyukha, V, Coers, J, Yamamoto, M, Isberg, RR, and Poltorak, A. "Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses." Cell Reports 24, no. 1 (July 2018): 155-168.e5.

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Piro, AS, Hernandez, D, Luoma, S, Feeley, EM, Finethy, R, Yirga, A, Frickel, EM, Lesser, CF, and Coers, J. "Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility." Mbio 8, no. 6 (December 12, 2017).

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Biering, SB, Choi, J, Halstrom, RA, Brown, HM, Beatty, WL, Lee, S, McCune, BT, Dominici, E, Williams, LE, Orchard, RC, Wilen, CB, Yamamoto, M, Coers, J, Taylor, GA, and Hwang, S. "Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases." Cell Host & Microbe 22, no. 1 (July 2017): 74-85.e7.

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Schmidt, EA, Fee, BE, Henry, SC, Nichols, AG, Shinohara, ML, Rathmell, JC, MacIver, NJ, Coers, J, Ilkayeva, OR, Koves, TR, and Taylor, GA. "Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages." The Journal of Biological Chemistry 292, no. 11 (March 2017): 4651-4662.

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Feeley, EM, Pilla-Moffett, DM, Zwack, EE, Piro, AS, Finethy, R, Kolb, JP, Martinez, J, Brodsky, IE, and Coers, J. "Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems." Proceedings of the National Academy of Sciences of the United States of America 114, no. 9 (February 13, 2017): E1698-E1706.

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Sixt, BS, Bastidas, RJ, Finethy, R, Baxter, RM, Carpenter, VK, Kroemer, G, Coers, J, and Valdivia, RH. "The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs." Cell Host & Microbe 21, no. 1 (January 2017): 113-121.

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Haldar, AK, Piro, AS, Finethy, R, Espenschied, ST, Brown, HE, Giebel, AM, Frickel, E-M, Nelson, DE, and Coers, J. "Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells." Mbio 7, no. 6 (December 13, 2016).

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Finethy, R, and Coers, J. "Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis." FEMS microbiology reviews 40, no. 6 (November 2016): 875-893. (Review)

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Pilla-Moffett, D, Barber, MF, Taylor, GA, and Coers, J. "Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease." Journal of Molecular Biology 428, no. 17 (August 2016): 3495-3513. (Review)

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Finethy, R, Jorgensen, I, Haldar, AK, de Zoete, MR, Strowig, T, Flavell, RA, Yamamoto, M, Nagarajan, UM, Miao, EA, and Coers, J. "Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages." Infection and Immunity 83, no. 12 (December 2015): 4740-4749.

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Pilla, DM, Hagar, JA, Haldar, AK, Mason, AK, Degrandi, D, Pfeffer, K, Ernst, RK, Yamamoto, M, Miao, EA, and Coers, J. "Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS." Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 8, 2014): 6046-6051.

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Coers, J. "Self and non-self discrimination of intracellular membranes by the innate immune system." Plos Pathog 9, no. 9 (September 2013): e1003538-null.

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Haldar, AK, Saka, HA, Piro, AS, Dunn, JD, Henry, SC, Taylor, GA, Frickel, EM, Valdivia, RH, and Coers, J. "IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins." Plos Pathog 9, no. 6 (2013): e1003414-null.

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Coers, J, Bernstein-Hanley, I, Grotsky, D, Parvanova, I, Howard, JC, Taylor, GA, Dietrich, WF, and Starnbach, MN. "Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10." J Immunol 180, no. 9 (May 1, 2008): 6237-6245.

Scholars@Duke

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