Haldar, AK, Piro, AS, Finethy, R, Espenschied, ST, Brown, HE, Giebel, AM, Frickel, E-M, Nelson, DE, and Coers, J. "Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells." mBio 7, no. 6 (December 13, 2016).
Jorn Coers, PhD
Education and Training
- Ph.D., University of Basel, 2004
Selected Grants and Awards
- Host-mediated lysis of cytoplasmic pathogens
- Genetics Training Grant
- Organization and Function of Cellular Structure
- Basic Immunology Training Program
- Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells
- Innate immune recognition of bacterial secretion systems by GBPs
- IRGM-driven host responses to Chlamydia trachomatis infections
- Targeting of Interferon-induced host proteins to Legionella-containing vacuoles
Pilla-Moffett, D, Barber, MF, Taylor, GA, and Coers, J. "Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease." Journal of molecular biology 428, no. 17 (August 2016): 3495-3513. (Review)
Finethy, R, and Coers, J. "Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis." FEMS microbiology reviews (July 29, 2016). (Review)
Finethy, R, Jorgensen, I, Haldar, AK, de Zoete, MR, Strowig, T, Flavell, RA, Yamamoto, M, Nagarajan, UM, Miao, EA, and Coers, J. "Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages." Infection and immunity 83, no. 12 (December 2015): 4740-4749.
Pilla, DM, Hagar, JA, Haldar, AK, Mason, AK, Degrandi, D, Pfeffer, K, Ernst, RK, Yamamoto, M, Miao, EA, and Coers, J. "Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS." Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 8, 2014): 6046-6051.
Coers, J. "Self and non-self discrimination of intracellular membranes by the innate immune system." PLoS Pathog 9, no. 9 (September 2013): e1003538-.
Haldar, AK, Saka, HA, Piro, AS, Dunn, JD, Henry, SC, Taylor, GA, Frickel, EM, Valdivia, RH, and Coers, J. "IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins." PLoS Pathog 9, no. 6 (2013): e1003414-.
Coers, J, Gondek, DC, Olive, AJ, Rohlfing, A, Taylor, GA, and Starnbach, MN. "Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections." PLoS Pathog 7, no. 6 (June 2011): e1001346-.
Coers, J, Bernstein-Hanley, I, Grotsky, D, Parvanova, I, Howard, JC, Taylor, GA, Dietrich, WF, and Starnbach, MN. "Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10." J Immunol 180, no. 9 (May 1, 2008): 6237-6245.
Coers, J, Vance, RE, Fontana, MF, and Dietrich, WF. "Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways." Cell Microbiol 9, no. 10 (October 2007): 2344-2357.
Bernstein-Hanley, I, Coers, J, Balsara, ZR, Taylor, GA, Starnbach, MN, and Dietrich, WF. "The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice." Proc Natl Acad Sci U S A 103, no. 38 (September 19, 2006): 14092-14097.
Bernstein-Hanley, I, Balsara, ZR, Ulmer, W, Coers, J, Starnbach, MN, and Dietrich, WF. "Genetic analysis of susceptibility to Chlamydia trachomatis in mouse." Genes Immun 7, no. 2 (March 2006): 122-129.