Jorn Coers, PhD
Education and Training
- Ph.D., University of Basel, 2004
Selected Grants and Awards
- Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis
- Medical Scientist Training Program
- Host-mediated lysis of cytoplasmic pathogens
- Genetics Training Grant
- Organization and Function of Cellular Structure
- Human GBPs in cell-autonomous immunity to intracellular bacterial pathogens
- Basic Immunology Training Program
- Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells
- Innate immune recognition of bacterial secretion systems by GBPs
- Targeting of Interferon-induced host proteins to Legionella-containing vacuoles
Liu, Beiyun C., Joseph Sarhan, Alexander Panda, Hayley I. Muendlein, Vladimir Ilyukha, Jörn Coers, Masahiro Yamamoto, Ralph R. Isberg, and Alexander Poltorak. “Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses..” Cell Rep 24, no. 1 (July 3, 2018): 155-168.e5. https://doi.org/10.1016/j.celrep.2018.06.012.
Piro, Anthony S., Dulcemaria Hernandez, Sarah Luoma, Eric M. Feeley, Ryan Finethy, Azeb Yirga, Eva M. Frickel, Cammie F. Lesser, and Jörn Coers. “Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility..” Mbio 8, no. 6 (December 12, 2017). https://doi.org/10.1128/mBio.01979-17.
Biering, Scott B., Jayoung Choi, Rachel A. Halstrom, Hailey M. Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, et al. “Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases..” Cell Host Microbe 22, no. 1 (July 12, 2017): 74-85.e7. https://doi.org/10.1016/j.chom.2017.06.005.
Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages..” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.
Feeley, Eric M., Danielle M. Pilla-Moffett, Erin E. Zwack, Anthony S. Piro, Ryan Finethy, Joseph P. Kolb, Jennifer Martinez, Igor E. Brodsky, and Jörn Coers. “Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems..” Proc Natl Acad Sci U S A 114, no. 9 (February 28, 2017): E1698–1706. https://doi.org/10.1073/pnas.1615771114.
Sixt, Barbara S., Robert J. Bastidas, Ryan Finethy, Ryan M. Baxter, Victoria K. Carpenter, Guido Kroemer, Jörn Coers, and Raphael H. Valdivia. “The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs..” Cell Host Microbe 21, no. 1 (January 11, 2017): 113–21. https://doi.org/10.1016/j.chom.2016.12.002.
Haldar, Arun K., Anthony S. Piro, Ryan Finethy, Scott T. Espenschied, Hannah E. Brown, Amanda M. Giebel, Eva-Maria Frickel, David E. Nelson, and Jörn Coers. “Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells..” Mbio 7, no. 6 (December 13, 2016). https://doi.org/10.1128/mBio.01417-16.
Finethy, Ryan, Ine Jorgensen, Arun K. Haldar, Marcel R. de Zoete, Till Strowig, Richard A. Flavell, Masahiro Yamamoto, Uma M. Nagarajan, Edward A. Miao, and Jörn Coers. “Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages..” Infect Immun 83, no. 12 (December 2015): 4740–49. https://doi.org/10.1128/IAI.00856-15.
Pilla, Danielle M., Jon A. Hagar, Arun K. Haldar, Ashley K. Mason, Daniel Degrandi, Klaus Pfeffer, Robert K. Ernst, Masahiro Yamamoto, Edward A. Miao, and Jörn Coers. “Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS..” Proc Natl Acad Sci U S A 111, no. 16 (April 22, 2014): 6046–51. https://doi.org/10.1073/pnas.1321700111.
Haldar, Arun K., Hector A. Saka, Anthony S. Piro, Joe Dan Dunn, Stanley C. Henry, Gregory A. Taylor, Eva M. Frickel, Raphael H. Valdivia, and Jörn Coers. “IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins..” Plos Pathog 9, no. 6 (2013). https://doi.org/10.1371/journal.ppat.1003414.
Coers, Jörn, Isaac Bernstein-Hanley, David Grotsky, Iana Parvanova, Jonathan C. Howard, Gregory A. Taylor, William F. Dietrich, and Michael N. Starnbach. “Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10..” J Immunol 180, no. 9 (May 1, 2008): 6237–45. https://doi.org/10.4049/jimmunol.180.9.6237.