Coers, J, Brown, HM, Hwang, S, and Taylor, GA. "Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense." Current Opinion in Immunology 54 (October 2018): 93-101. (Review)
Jorn Coers, PhD
Education and Training
- Ph.D., University of Basel, 2004
Selected Grants and Awards
- Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis
- Medical Scientist Training Program
- Host-mediated lysis of cytoplasmic pathogens
- Genetics Training Grant
- Organization and Function of Cellular Structure
- Human GBPs in cell-autonomous immunity to intracellular bacterial pathogens
- Basic Immunology Training Program
- Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells
- Innate immune recognition of bacterial secretion systems by GBPs
- Targeting of Interferon-induced host proteins to Legionella-containing vacuoles
Liu, BC, Sarhan, J, Panda, A, Muendlein, HI, Ilyukha, V, Coers, J, Yamamoto, M, Isberg, RR, and Poltorak, A. "Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses." Cell Reports 24, no. 1 (July 2018): 155-168.e5.
Piro, AS, Hernandez, D, Luoma, S, Feeley, EM, Finethy, R, Yirga, A, Frickel, EM, Lesser, CF, and Coers, J. "Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility." Mbio 8, no. 6 (December 12, 2017).
Biering, SB, Choi, J, Halstrom, RA, Brown, HM, Beatty, WL, Lee, S, McCune, BT, Dominici, E, Williams, LE, Orchard, RC, Wilen, CB, Yamamoto, M, Coers, J, Taylor, GA, and Hwang, S. "Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases." Cell Host & Microbe 22, no. 1 (July 2017): 74-85.e7.
Schmidt, EA, Fee, BE, Henry, SC, Nichols, AG, Shinohara, ML, Rathmell, JC, MacIver, NJ, Coers, J, Ilkayeva, OR, Koves, TR, and Taylor, GA. "Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages." The Journal of Biological Chemistry 292, no. 11 (March 2017): 4651-4662.
Feeley, EM, Pilla-Moffett, DM, Zwack, EE, Piro, AS, Finethy, R, Kolb, JP, Martinez, J, Brodsky, IE, and Coers, J. "Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems." Proceedings of the National Academy of Sciences of the United States of America 114, no. 9 (February 13, 2017): E1698-E1706.
Sixt, BS, Bastidas, RJ, Finethy, R, Baxter, RM, Carpenter, VK, Kroemer, G, Coers, J, and Valdivia, RH. "The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs." Cell Host & Microbe 21, no. 1 (January 2017): 113-121.
Haldar, AK, Piro, AS, Finethy, R, Espenschied, ST, Brown, HE, Giebel, AM, Frickel, E-M, Nelson, DE, and Coers, J. "Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells." Mbio 7, no. 6 (December 13, 2016).
Finethy, R, and Coers, J. "Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis." FEMS microbiology reviews 40, no. 6 (November 2016): 875-893. (Review)
Pilla-Moffett, D, Barber, MF, Taylor, GA, and Coers, J. "Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease." Journal of Molecular Biology 428, no. 17 (August 2016): 3495-3513. (Review)
Finethy, R, Jorgensen, I, Haldar, AK, de Zoete, MR, Strowig, T, Flavell, RA, Yamamoto, M, Nagarajan, UM, Miao, EA, and Coers, J. "Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages." Infection and Immunity 83, no. 12 (December 2015): 4740-4749.
Pilla, DM, Hagar, JA, Haldar, AK, Mason, AK, Degrandi, D, Pfeffer, K, Ernst, RK, Yamamoto, M, Miao, EA, and Coers, J. "Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS." Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 8, 2014): 6046-6051.
Coers, J. "Self and non-self discrimination of intracellular membranes by the innate immune system." Plos Pathog 9, no. 9 (September 2013): e1003538-null.
Haldar, AK, Saka, HA, Piro, AS, Dunn, JD, Henry, SC, Taylor, GA, Frickel, EM, Valdivia, RH, and Coers, J. "IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins." Plos Pathog 9, no. 6 (2013): e1003414-null.
Coers, J, Bernstein-Hanley, I, Grotsky, D, Parvanova, I, Howard, JC, Taylor, GA, Dietrich, WF, and Starnbach, MN. "Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10." Journal of Immunology (Baltimore, Md. : 1950) 180, no. 9 (May 2008): 6237-6245.