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Michael M. Frank, MD

Samuel L. Katz Professor of Pediatrics, in the School of Medicine
Campus Mail: 131 MSRB, Durham, NC 27710
Phone: (919) 684-2922
Email: frank007@mc.duke.edu

The research of Dr. Frank's laboratory revolves around effector mechanisms of immune damage. Specifically, the laboratory is interested in understanding how antibody and complement contribute to the damage of tissues and micro-organisms. Overlapping areas of interest include the role of mediators in inflammation and the functions of antibody and complement in the production of autoimmune disease. Specific interests of the group in the last year have included studies of the mechanism by which infusion of intravenous immunoglobulin into animals and man down regulates immunologic damage. A second area of interest concerns the role of complement and antibody in the pathogenesis of HIV and in prevention of HIV infection. A third area concerns the role of complement in the generation of an immune response. A long term interest has been in the clinical signs and appropriate treatment of patients with hereditary angioedema.

Education and Training

  • M.D., Harvard University, 1960

Selected Publications

Frank, MM. "8. Hereditary angioedema." J Allergy Clin Immunol 121, no. 2 Suppl (February 2008): S398-S401. (Review)

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Frank, MM, and Jiang, H. "New therapies for hereditary angioedema: disease outlook changes dramatically." J Allergy Clin Immunol 121, no. 1 (January 2008): 272-280.

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Frank, MM, and Atkinson, JP. "Homozygous C1 inhibitor deficiency: The conclusion of a long search." J Allergy Clin Immunol 118, no. 6 (December 2006): 1327-1329.

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Atkinson, JP, and Frank, MM. "Bypassing complement: evolutionary lessons and future implications." J Clin Invest 116, no. 5 (May 2006): 1215-1218.

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Jiang, H, Wang, Z, Serra, D, Frank, MM, and Amalfitano, A. "Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies." Mol Ther 10, no. 6 (December 2004): 1140-1142.

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Frank, MM. "Hereditary angioedema: a half century of progress." J Allergy Clin Immunol 114, no. 3 (September 2004): 626-628.

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Cunnion, KM, Benjamin, DK, Hester, CG, and Frank, MM. "Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia." J Lab Clin Med 143, no. 6 (June 2004): 358-365.

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Cunnion, KM, and Frank, MM. "Complement activation influences Staphylococcus aureus adherence to endothelial cells." Infect Immun 71, no. 3 (March 2003): 1321-1327.

Scholars@Duke

Cunnion, KM, Zhang, H-M, and Frank, MM. "Availability of complement bound to Staphylococcus aureus to interact with membrane complement receptors influences efficiency of phagocytosis." Infect Immun 71, no. 2 (February 2003): 656-662.

Scholars@Duke

Watford, WT, Smithers, MB, Frank, MM, and Wright, JR. "Surfactant protein A enhances the phagocytosis of C1q-coated particles by alveolar macrophages." Am J Physiol Lung Cell Mol Physiol 283, no. 5 (November 2002): L1011-L1022.

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Frank, MM. "The "neurotic" edema: the parent disease and its offspring." Am J Med 113, no. 3 (August 15, 2002): 249-251.

Scholars@Duke

McCann, WA, Frank, MM, Cox, F, and Ownby, DR. "Haemophilus influenzae type b meningitis in a fully immunized 2-year-old." Ann Allergy Asthma Immunol 88, no. 6 (June 2002): 551-555.

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Jiang, H, Wagner, E, Zhang, H, and Frank, MM. "Complement 1 inhibitor is a regulator of the alternative complement pathway." J Exp Med 194, no. 11 (December 3, 2001): 1609-1616.

Scholars@Duke

Frank, MM. "Annihilating host defense." Nat Med 7, no. 12 (December 2001): 1285-1286.

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Watford, WT, Wright, JR, Hester, CG, Jiang, H, and Frank, MM. "Surfactant protein A regulates complement activation." J Immunol 167, no. 11 (December 1, 2001): 6593-6600.

Scholars@Duke

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