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Minghua Zhu, PhD

Assistant Research Professor of Immunology
Campus Mail: 106 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7887
Email: zhu00004@mc.duke.edu

Education and Training

  • Postdoctoral Fellow, Laboratory Of Molecular Immunology, National Institutes of Health, 1995 - 1999
  • Ph.D., Yeshiva University New York, 1995

Selected Publications

Zhu, M, Koonpaew, S, Liu, Y, Shen, S, Denning, T, Dzhagalov, I, Rhee, I, and Zhang, W. "Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB." Immunity 25, no. 5 (November 2006): 757-768.

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Zhu, M, Granillo, O, Wen, R, Yang, K, Dai, X, Wang, D, and Zhang, W. "Negative regulation of lymphocyte activation by the adaptor protein LAX." J Immunol 174, no. 9 (May 1, 2005): 5612-5619.

Scholars@Duke

Zhu, M, Shen, S, Liu, Y, Granillo, O, and Zhang, W. "Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development." J Immunol 174, no. 1 (January 1, 2005): 31-35.

Scholars@Duke

Zhu, M, Liu, Y, Koonpaew, S, Granillo, O, and Zhang, W. "Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL." J Exp Med 200, no. 8 (October 18, 2004): 991-1000.

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Janssen, E, Zhu, M, Craven, B, and Zhang, W. "Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding." J Immunol 172, no. 11 (June 1, 2004): 6810-6819.

Scholars@Duke

Koonpaew, S, Janssen, E, Zhu, M, and Zhang, W. "The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB." J Biol Chem 279, no. 12 (March 19, 2004): 11229-11235.

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Janssen, E, Zhu, M, Zhang, W, Koonpaew, S, and Zhang, W. "LAB: a new membrane-associated adaptor molecule in B cell activation." Nat Immunol 4, no. 2 (February 2003): 117-123.

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Zhu, M, Janssen, E, and Zhang, W. "Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development." J Immunol 170, no. 1 (January 1, 2003): 325-333.

Scholars@Duke

Zhu, M, Janssen, E, Leung, K, and Zhang, W. "Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling." J Biol Chem 277, no. 48 (November 29, 2002): 46151-46158.

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Zhang, W, Trible, RP, Zhu, M, Liu, SK, McGlade, CJ, and Samelson, LE. "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling." J Biol Chem 275, no. 30 (July 28, 2000): 23355-23361.

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