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Peter Edward Fecci, MD, PhD

Associate Professor of Neurosurgery
Campus Mail: 201 Sands Bldg., Box 3050, Durham, NC 27710
Phone: (919) 681-1010
Email: peter.fecci@duke.edu

As the Director of both the Brain Tumor Immunotherapy Program and the Center for Brain and Spine Metastasis at Duke University, I focus our programmatic interests on the design, optimization, and monitoring of immune-based treatment platforms for patients with intracranial tumors, whether primary or metastatic. Within this broad scope, however, my own group looks more specifically at limitations to immunotherapeutic success, with a particular focus on understanding and reversing T cell dysfunction in patients with glioblastoma (GBM) and brain metastases. We employ a systematic approach to categorizing T cell dysfunction (Woroniecka et al, Clin Cancer Res 2018 Aug 15;24(16):3792-3802), and whereas our earlier work addressed concerns for regulatory T cell-induced tolerance, we now heavily study T cell ignorance and exhaustion, as well. Regarding the former, we recently published the novel phenomenon of S1P1-mediated bone marrow T cell sequestration in patients with intracranial tumors (Chongsathidkiet et al, Nat Medicine 2018 Sep;24(9):1459-1468). Regarding the latter, we have likewise recently identified and characterized exhaustion as a significant limitation to T-cell function within GBM (Woroniecka et al, Clin Cancer Res 2018 Sep 1;24(17):4175-4186). I very much look to collaboratively integrate our approaches with others investigating innovative treatment options. I continue my focus on combining strategies for reversing T cell deficits with current and novel immune-based platforms as a means of deriving and improving rational and precise anti-tumor therapies. It is my sincerest desire to forge a career focused on co-operative, multi-disciplinary, organized brain tumor therapy. Ultimately, my goal is to help coordinate the efforts of a streamlined and effective center for brain tumor research and clinical care. I hope to play some role in ushering in a period where the science and treatment arms of brain tumor therapy suffer no disjoint, but instead represent the convergent efforts of researchers, neuro-oncologists, medical oncologists, radiation oncologists, biomedical engineers, and neurosurgeons alike. I hope to see such synergy become standard of care.

Education and Training

  • Instructor, Neurosurgery, Massachusetts General Hospital, 2013 - 2014
  • Postdoctoral Fellow, Dana-Farber Cancer Institute, 2010 - 2012
  • Residency, Neurosurgery, Massachusetts General Hospital, 2008 - 2013
  • Internship, General Surgery, Massachusetts General Hospital, 2007 - 2008
  • Ph.D., Duke University, 2007
  • M.D., Duke University School of Medicine, 2007

Selected Grants and Awards

Selected Publications

Shen, Steven H., Karolina Woroniecka, Andrew B. Barbour, Peter E. Fecci, Luis Sanchez-Perez, and John H. Sampson. “CAR T cells and checkpoint inhibition for the treatment of glioblastoma.” Expert Opin Biol Ther 20, no. 6 (June 2020): 579–91. https://doi.org/10.1080/14712598.2020.1727436.

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Moravan, Michael J., Peter E. Fecci, Carey K. Anders, Jeffrey M. Clarke, April K. S. Salama, Justus D. Adamson, Scott R. Floyd, et al. “Current multidisciplinary management of brain metastases.” Cancer 126, no. 7 (April 1, 2020): 1390–1406. https://doi.org/10.1002/cncr.32714.

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Kemeny, Hanna R., Aladine A. Elsamadicy, S Harrison Farber, Cosette D. Champion, Selena J. Lorrey, Pakawat Chongsathidkiet, Karolina I. Woroniecka, et al. “Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease.” Clin Cancer Res 26, no. 5 (March 1, 2020): 1141–51. https://doi.org/10.1158/1078-0432.CCR-18-3486.

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Huang, Min-Nung, Lowell T. Nicholson, Kristen A. Batich, Adam M. Swartz, David Kopin, Sebastian Wellford, Vijay K. Prabhakar, et al. “Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses.” J Clin Invest 130, no. 2 (February 3, 2020): 774–88. https://doi.org/10.1172/JCI128267.

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Mohammadi, Alireza M., Mayur Sharma, Thomas L. Beaumont, Kevin O. Juarez, Hanna Kemeny, Cosette Dechant, Andreas Seas, et al. “Upfront Magnetic Resonance Imaging-Guided Stereotactic Laser-Ablation in Newly Diagnosed Glioblastoma: A Multicenter Review of Survival Outcomes Compared to a Matched Cohort of Biopsy-Only Patients.” Neurosurgery 85, no. 6 (December 1, 2019): 762–72. https://doi.org/10.1093/neuros/nyy449.

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Fecci, Peter E., Cosette D. Champion, Jacob Hoj, Courtney M. McKernan, C Rory Goodwin, John P. Kirkpatrick, Carey K. Anders, Ann Marie Pendergast, and John H. Sampson. “The Evolving Modern Management of Brain Metastasis.” Clin Cancer Res 25, no. 22 (November 15, 2019): 6570–80. https://doi.org/10.1158/1078-0432.CCR-18-1624.

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Sankey, Eric W., Vadim Tsvankin, Matthew M. Grabowski, Gautam Nayar, Kristen A. Batich, Aida Risman, Cosette D. Champion, April K. S. Salama, C Rory Goodwin, and Peter E. Fecci. “Operative and peri-operative considerations in the management of brain metastasis.” Cancer Med 8, no. 16 (November 2019): 6809–31. https://doi.org/10.1002/cam4.2577.

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Liu, Yang, Pakawat Chongsathidkiet, Bridget M. Crawford, Ren Odion, Cosette A. Dechant, Hanna R. Kemeny, Xiuyu Cui, et al. “Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory.” Immunotherapy 11, no. 15 (October 2019): 1293–1302. https://doi.org/10.2217/imt-2019-0023.

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Choi, Kevin J., Feras Y. Ackall, Tracy Truong, Tracy Z. Cheng, Maragatha Kuchibhatla, Ali R. Zomorodi, Patrick J. Codd, Peter E. Fecci, Ralph Abi Hachem, and David W. Jang. “Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base.” J Neurol Surg B Skull Base 80, no. 4 (August 2019): 416–23. https://doi.org/10.1055/s-0038-1675592.

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Chongsathidkiet, Pakawat, Christina Jackson, Shohei Koyama, Franziska Loebel, Xiuyu Cui, S Harrison Farber, Karolina Woroniecka, et al. “Author Correction: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.” Nat Med 25, no. 3 (March 2019): 529. https://doi.org/10.1038/s41591-019-0355-0.

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Natarajan, Brahma D., Christel N. Rushing, Michael A. Cummings, Jessica Ms Jutzy, Kingshuk R. Choudhury, Michael J. Moravan, Peter E. Fecci, et al. “Predicting intracranial progression following stereotactic radiosurgery for brain metastases: Implications for post SRS imaging.” J Radiosurg Sbrt 6, no. 3 (2019): 179–87.

Scholars@Duke

Suryadevara, Carter M., Rupen Desai, S Harrison Farber, Bryan D. Choi, Adam M. Swartz, Steven H. Shen, Patrick C. Gedeon, et al. “Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.” Clin Cancer Res 25, no. 1 (January 1, 2019): 358–68. https://doi.org/10.1158/1078-0432.CCR-18-1211.

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