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Thomas B. Kepler, PhD

Adjunct Professor in the Department of Immunology
Campus Mail: 2424 Erwin Road Suite 1102, 11103D Hock Plaza, Durham, NC 27705-3858
Phone: (919) 681-0620
Email: kepler@duke.edu

Computational and Systems Immunology, Theoretical and Evolutionary Medicine

Education and Training

  • Associate Professor And Director, Biomathematics Gp & Statistics Dept., North Carolina State University, 1998 - 2000
  • Assistant Professor, Biomathematics Graduate Program, North Carolina State University, 1993 - 1998
  • Postdoctoral Fellowship, Brandeis University, 1989 - 1991
  • Ph.D., Brandeis University, 1989
  • B.A., University of Massachusetts at Amherst, 1985

Selected Publications

Ray, S, and Kepler, TB. "Amino acid biophysical properties in the statistical prediction of peptide-MHC class I binding. (Published online)" Immunome Res 3 (October 29, 2007): 9-.

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Markert, ML, Devlin, BH, Alexieff, MJ, Li, J, McCarthy, EA, Gupton, SE, Chinn, IK, Hale, LP, Kepler, TB, He, M, Sarzotti, M, Skinner, MA, Rice, HE, and Hoehner, JC. "Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants." Blood 109, no. 10 (May 15, 2007): 4539-4547.

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Kepler, TB, and Chan, C. "Spatiotemporal programming of a simple inflammatory process." Immunol Rev 216 (April 2007): 153-163. (Review)

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Chan, C, and Kepler, TB. "Computational immunology--from bench to virtual reality." Ann Acad Med Singapore 36, no. 2 (February 2007): 123-127. (Review)

Scholars@Duke

Culton, DA, Nicholas, MW, Bunch, DO, Zhen, QL, Kepler, TB, Dooley, MA, Mohan, C, Nachman, PH, and Clarke, SH. "Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss." J Clin Immunol 27, no. 1 (January 2007): 53-68.

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Bauer, DC, Hunter, DJ, Abramson, SB, Attur, M, Corr, M, Felson, D, Heinegård, D, Jordan, JM, Kepler, TB, Lane, NE, Saxne, T, Tyree, B, Kraus, VB, and Osteoarthritis Biomarkers Network, . "Classification of osteoarthritis biomarkers: a proposed approach." Osteoarthritis Cartilage 14, no. 8 (August 2006): 723-727. (Review)

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Liu, C, He, M, Rooney, B, Kepler, TB, and Chao, NJ. "Longitudinal analysis of T-cell receptor variable beta chain repertoire in patients with acute graft-versus-host disease after allogeneic stem cell transplantation." Biol Blood Marrow Transplant 12, no. 3 (March 2006): 335-345.

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Volpe, JM, Cowell, LG, and Kepler, TB. "SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations." Bioinformatics 22, no. 4 (February 15, 2006): 438-444.

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Fadel, SA, Cowell, LG, Cao, S, Ozaki, DA, Kepler, TB, Steeber, DA, and Sarzotti, M. "Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection." Int Immunol 18, no. 2 (February 2006): 249-257.

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He, M, Tomfohr, JK, Devlin, BH, Sarzotti, M, Markert, ML, and Kepler, TB. "SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization." Bioinformatics 21, no. 18 (September 15, 2005): 3697-3699.

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Tomfohr, J, Lu, J, and Kepler, TB. "Pathway level analysis of gene expression using singular value decomposition. (Published online)" BMC Bioinformatics 6 (September 12, 2005): 225-.

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Kepler, TB, He, M, Tomfohr, JK, Devlin, BH, Sarzotti, M, and Markert, ML. "Statistical analysis of antigen receptor spectratype data." Bioinformatics 21, no. 16 (August 15, 2005): 3394-3400.

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Lu, J, Tomfohr, JK, and Kepler, TB. "Identifying differential expression in multiple SAGE libraries: an overdispersed log-linear model approach. (Published online)" BMC Bioinformatics 6 (June 29, 2005): 165-.

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Smith, JT, Tomfohr, JK, Wells, MC, Beebe, TP, Kepler, TB, and Reichert, WM. "Measurement of cell migration on surface-bound fibronectin gradients." Langmuir 20, no. 19 (September 14, 2004): 8279-8286.

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Zhang, S-M, Adema, CM, Kepler, TB, and Loker, ES. "Diversification of Ig superfamily genes in an invertebrate." Science 305, no. 5681 (July 9, 2004): 251-254.

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