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Thomas Fletcher Tedder, PhD

Alter Geller Professor for Research in Immunology in the School of Medicine
Campus Mail: 353 Jones Building, 207 Resear, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 684-3681
Email: thomas.tedder@duke.edu

Area of Study: Structure and function of B lymphocyte cell surface molecules that regulate B cell function, activation and signal transduction.

Overview: The focus of our laboratory is the identification, structural characterization, and functional analysis of cell surface molecules and signaling pathways that regulate B lymphocyte development and function. Cell surface molecules allow B cells to communicate with the extracellular environment by serving as transmembrane regulators, receptors for soluble factors, or by mediating cell–cell interactions. Our studies of B-cell–associated cell surface receptors, including CD19, CD20, CD21, CD22 and CD83, are aimed at determining how these molecules function, what their ligands are, how they generate transmembrane signals and regulate human and mouse B cell development, survival and activation. These studies lay the foundation for investigating mechanisms of immune dysregulation and the pathogenesis of immune disorders, such as autoimmunity, neoplastic transformation, and immunodeficiency syndromes in humans. We have expertise in cellular immunology, biochemistry, and molecular biology and are applying a wide range of techniques in understanding the regulatory pathways that govern normal and abnormal B cell function in mice and humans. Current studies are focused on identifying the molecular and cellular mechanisms by which B cells regulate T cell function and autoimmunity, with a particular emphasis on the regulatory B cell subset (B10 cells) that controls immune and inflammatory responses through their production IL-10, a potent negative regulatory cytokine. Current studies also focus on identifying the molecular and cellular mechanisms by which CD19, CD20 and CD22 mAb immunotherapies are effective for treating B cell malignancies and autoimmunity, with translational studies pursuing the development of molecular and cellular therapies for human disease.

We currently have open positions for Research Scientist appointments, students, and postdoctoral fellows.

Education and Training

  • Ph.D., University of Alabama at Birmingham, 1984

Selected Publications

Winer, DA, Winer, S, Shen, L, Wadia, PP, Yantha, J, Paltser, G, Tsui, H, Wu, P, Davidson, MG, Alonso, MN, Leong, HX, Glassford, A, Caimol, M, Kenkel, JA, Tedder, TF, McLaughlin, T, Miklos, DB, Dosch, H-M, and Engleman, EG. "B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies." Nat Med 17, no. 5 (May 2011): 610-617.

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DiLillo, DJ, Horikawa, M, and Tedder, TF. "B-lymphocyte effector functions in health and disease." Immunol Res 49, no. 1-3 (April 2011): 281-292. (Review)

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Kohrt, HE, Houot, R, Goldstein, MJ, Weiskopf, K, Alizadeh, AA, Brody, J, Müller, A, Pachynski, R, Czerwinski, D, Coutre, S, Chao, MP, Chen, L, Tedder, TF, and Levy, R. "CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies." Blood 117, no. 8 (February 24, 2011): 2423-2432.

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Pellegrini, M, Calzascia, T, Toe, JG, Preston, SP, Lin, AE, Elford, AR, Shahinian, A, Lang, PA, Lang, KS, Morre, M, Assouline, B, Lahl, K, Sparwasser, T, Tedder, TF, Paik, J-H, DePinho, RA, Basta, S, Ohashi, PS, and Mak, TW. "IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology." Cell 144, no. 4 (February 18, 2011): 601-613.

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DiLillo, DJ, Griffiths, R, Seshan, SV, Magro, CM, Ruiz, P, Coffman, TM, and Tedder, TF. "B lymphocytes differentially influence acute and chronic allograft rejection in mice." J Immunol 186, no. 4 (February 15, 2011): 2643-2654.

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Yanaba, K, Yoshizaki, A, Asano, Y, Kadono, T, Tedder, TF, and Sato, S. "IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model." Am J Pathol 178, no. 2 (February 2011): 735-743.

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Iwata, Y, Matsushita, T, Horikawa, M, Dilillo, DJ, Yanaba, K, Venturi, GM, Szabolcs, PM, Bernstein, SH, Magro, CM, Williams, AD, Hall, RP, St Clair, EW, and Tedder, TF. "Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells." Blood 117, no. 2 (January 13, 2011): 530-541.

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Poe, JC, Smith, SH, Haas, KM, Yanaba, K, Tsubata, T, Matsushita, T, and Tedder, TF. "Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice." PLoS One 6, no. 7 (2011): e22464-.

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Matsushita, T, and Tedder, TF. "Identifying regulatory B cells (B10 cells) that produce IL-10 in mice." Methods Mol Biol 677 (2011): 99-111.

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Carlson, MJ, Fulton, LM, Coghill, JM, West, ML, Burgents, JE, Wan, Y, Panoskaltsis-Mortari, A, Tedder, TF, Blazar, BR, and Serody, JS. "L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation." Am J Transplant 10, no. 12 (December 2010): 2596-2603.

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Ohmatsu, H, Kadono, T, Sugaya, M, Tomita, M, Kai, H, Miyagaki, T, Saeki, H, Tamaki, K, Steeber, DA, Tedder, TF, and Sato, S. "α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin." J Allergy Clin Immunol 126, no. 6 (December 2010): 1267-1276.

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Herbst, R, Wang, Y, Gallagher, S, Mittereder, N, Kuta, E, Damschroder, M, Woods, R, Rowe, DC, Cheng, L, Cook, K, Evans, K, Sims, GP, Pfarr, DS, Bowen, MA, Dall'Acqua, W, Shlomchik, M, Tedder, TF, Kiener, P, Jallal, B, Wu, H, and Coyle, AJ. "B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody." J Pharmacol Exp Ther 335, no. 1 (October 2010): 213-222.

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Yoshizaki, A, Yanaba, K, Iwata, Y, Komura, K, Ogawa, A, Akiyama, Y, Muroi, E, Hara, T, Ogawa, F, Takenaka, M, Shimizu, K, Hasegawa, M, Fujimoto, M, Tedder, TF, and Sato, S. "Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model." J Immunol 185, no. 4 (August 15, 2010): 2502-2515.

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Matsushita, T, Horikawa, M, Iwata, Y, and Tedder, TF. "Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis." J Immunol 185, no. 4 (August 15, 2010): 2240-2252.

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Ait-Oufella, H, Herbin, O, Bouaziz, J-D, Binder, CJ, Uyttenhove, C, Laurans, L, Taleb, S, Van Vré, E, Esposito, B, Vilar, J, Sirvent, J, Van Snick, J, Tedgui, A, Tedder, TF, and Mallat, Z. "B cell depletion reduces the development of atherosclerosis in mice." J Exp Med 207, no. 8 (August 2, 2010): 1579-1587.

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