Gurley, SB, Mach, CL, Stegbauer, J, Yang, J, Snow, KP, Hu, A, Meyer, TW, and Coffman, TM. "Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice." Am J Physiol Renal Physiol 298, no. 3 (March 2010): F788-F795.
Thomas Myron Coffman, MD
My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.
Education and Training
- Fellowship In Nephrology, Duke University School of Medicine, 1983 - 1985
- M.D., Ohio State University, 1980
Selected Grants and Awards
- Postdoctoral training in genomic medicine research
- Multidisciplinary Heart and Vascular Diseases
- Paracrine Control of Blood Pressure by Renal Intercalated Cells
- Actions of Angiotensin II Along the Nephron to Regulate Blood Pressure
- Training Program in Inflammatory and Immunological Diseases
- Student Supplement
- Role of Gq Signaling in Promoting Podocyte Injury in Diabetes Mellitus
- Immune Mechanisms in Diabetic Nephropathy
- Prostaglandin E2 and Regulation of Kidney Function
- A New Locus for Hereditary FSGS on Chromosome 2p
- Renal Endothelin-1: Control of Sodium Excretion and Blood Pressure
- A Novel Mouse Model of Podocyte Injury
- Characterization of TRPC6 As A Cause for Focal and Segmental Glomerulosclerosis
- Angiotensin Receptor Genes and Blood Pressure Regulation
- Genetic Determinants of Susceptibility to Kidney Disease in African Americans
- Angiogenic Signals in Diabetic Complications
- B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function
- IPA - Natalia Makhanova
- Pathophysiology of Renal Allograft Dysfunction
- Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects
- Role of mPGES1 in Regulation of Kidney Function
- IPA - Galen Hoover
- Actions of Angiotensin II in Vascular Smooth Muscle
- Rac, Superoxide and Antioxidants in Hypertension
- Genes that Regulate Target Organ Damage in Hypertension
- Duke-UNC-Stanford AMDC Unit
- Pathophysiology of Renal Allograft Dysfunction
- Pathophysiology of renal allograft dysfunction
- Pathophysiology of renal allograft dysfunction (Minority Suppl)
- Duke/NIDDK Functional Genomics Center
- Duke Training Grant in Nephrology
- Duke Training Grant In Nephrology
- Angiotensin receptor genes and blood pressure regulation
Facemire, CS, Griffiths, R, Audoly, LP, Koller, BH, and Coffman, TM. "The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background." Hypertension 55, no. 2 (February 2010): 531-538.
Facemire, CS, Nixon, AB, Griffiths, R, Hurwitz, H, and Coffman, TM. "Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression." Hypertension 54, no. 3 (September 2009): 652-658.
Crowley, SD, Vasievich, MP, Ruiz, P, Gould, SK, Parsons, KK, Pazmino, AK, Facemire, C, Chen, BJ, Kim, H-S, Tran, TT, Pisetsky, DS, Barisoni, L, Prieto-Carrasquero, MC, Jeansson, M, Foster, MH, and Coffman, TM. "Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis." J Clin Invest 119, no. 4 (April 2009): 943-953.
Benigni, A, Corna, D, Zoja, C, Sonzogni, A, Latini, R, Salio, M, Conti, S, Rottoli, D, Longaretti, L, Cassis, P, Morigi, M, Coffman, TM, and Remuzzi, G. "Disruption of the Ang II type 1 receptor promotes longevity in mice." J Clin Invest 119, no. 3 (March 2009): 524-530.
Coffman, TM, and Crowley, SD. "Kidney in hypertension: guyton redux." Hypertension 51, no. 4 (April 2008): 811-816. (Review)
Gurley, SB, and Coffman, TM. "The renin-angiotensin system and diabetic nephropathy." Semin Nephrol 27, no. 2 (March 2007): 144-152. (Review)
Crowley, SD, Gurley, SB, Herrera, MJ, Ruiz, P, Griffiths, R, Kumar, AP, Kim, H-S, Smithies, O, Le, TH, and Coffman, TM. "Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney." Proc Natl Acad Sci U S A 103, no. 47 (November 21, 2006): 17985-17990.
Coffman, TM. "A WNK in the kidney controls blood pressure." Nat Genet 38, no. 10 (October 2006): 1105-1106.
Gurley, SB, Allred, A, Le, TH, Griffiths, R, Mao, L, Philip, N, Haystead, TA, Donoghue, M, Breitbart, RE, Acton, SL, Rockman, HA, and Coffman, TM. "Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice." J Clin Invest 116, no. 8 (August 2006): 2218-2225.
Francois, H, Athirakul, K, Howell, D, Dash, R, Mao, L, Kim, H-S, Rockman, HA, Fitzgerald, GA, Koller, BH, and Coffman, TM. "Prostacyclin protects against elevated blood pressure and cardiac fibrosis." Cell Metab 2, no. 3 (September 2005): 201-207.
Crowley, SD, Gurley, SB, Oliverio, MI, Pazmino, AK, Griffiths, R, Flannery, PJ, Spurney, RF, Kim, H-S, Smithies, O, Le, TH, and Coffman, TM. "Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system." J Clin Invest 115, no. 4 (April 2005): 1092-1099.
Goulet, JL, Pace, AJ, Key, ML, Byrum, RS, Nguyen, M, Tilley, SL, Morham, SG, Langenbach, R, Stock, JL, McNeish, JD, Smithies, O, Coffman, TM, and Koller, BH. "E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation." J Immunol 173, no. 2 (July 15, 2004): 1321-1326.
Thomas, DW, Rocha, PN, Nataraj, C, Robinson, LA, Spurney, RF, Koller, BH, and Coffman, TM. "Proinflammatory actions of thromboxane receptors to enhance cellular immune responses." J Immunol 171, no. 12 (December 15, 2003): 6389-6395.
Rocha, PN, Plumb, TJ, and Coffman, TM. "Eicosanoids: lipid mediators of inflammation in transplantation." Springer Semin Immunopathol 25, no. 2 (September 2003): 215-227. (Review)