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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Campus Mail: 3704, Durham, NC 27710
Email: allan.kirk@duke.edu

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants and Awards

Selected Publications

Anderson, DJ, Lo, DJ, Leopardi, F, Song, M, Turgeon, NA, Strobert, EA, Jenkins, JB, Wang, R, Reimann, KA, Larsen, CP, and Kirk, AD. "Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 5 (May 2016): 1456-1464.

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Espinosa, J, Herr, F, Tharp, G, Bosinger, S, Song, M, Farris, AB, George, R, Cheeseman, J, Stempora, L, Townsend, R, Durrbach, A, and Kirk, AD. "CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 4 (April 2016): 1102-1112.

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Xu, H, Samy, KP, Guasch, A, Mead, SI, Ghali, A, Mehta, A, Stempora, L, and Kirk, AD. "Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 2 (February 2016): 550-564.

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Freedman, BI, Pastan, SO, Israni, AK, Schladt, D, Julian, BA, Gautreaux, MD, Hauptfeld, V, Bray, RA, Gebel, HM, Kirk, AD, Gaston, RS, Rogers, J, Farney, AC, Orlando, G, Stratta, RJ, Mohan, S, Ma, L, Langefeld, CD, Bowden, DW, Hicks, PJ, Palmer, ND, Palanisamy, A, Reeves-Daniel, AM, Brown, WM, and Divers, J. "APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors." Transplantation 100, no. 1 (January 2016): 194-202.

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Cooper, DKC, Bottino, R, Gianello, P, Graham, M, Hawthorne, WJ, Kirk, AD, Korsgren, O, Park, C-G, and Weber, C. "First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial." Xenotransplantation 23, no. 1 (January 2016): 46-52.

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Elder, RW, George, RP, McCabe, NM, Rodriguez, FH, Book, WM, Mahle, WT, and Kirk, AD. "Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?." Pediatric cardiology 36, no. 7 (October 2015): 1411-1416.

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Freitas, AM, Samy, KP, Farris, AB, Leopardi, FV, Song, M, Stempora, L, Strobert, EA, Jenkins, JA, Kirk, AD, and Cendales, LC. "Studies Introducing Costimulation Blockade for Vascularized Composite Allografts in Nonhuman Primates." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2240-2249.

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Cendales, L, Bray, R, Gebel, H, Brewster, L, Elbein, R, Farthing, D, Song, M, Parker, D, Stillman, A, Pearson, T, and Kirk, AD. "Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2250-2255.

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Beasley, GM, Pappas, TN, and Kirk, AD. "Procedure Delegation by Attending Surgeons Performing Concurrent Operations in Academic Medical Centers: Balancing Safety and Efficiency." Annals of surgery 261, no. 6 (June 2015): 1044-1045.

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Mou, D, Espinosa, JE, Stempora, L, Iwakoshi, NN, and Kirk, AD. "Viral-induced CD28 loss evokes costimulation independent alloimmunity." The Journal of surgical research 196, no. 2 (June 2015): 241-246.

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Lo, DJ, Anderson, DJ, Song, M, Leopardi, F, Farris, AB, Strobert, E, Chapin, S, Devens, B, Karrer, E, and Kirk, AD. "A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 4 (April 2015): 984-992.

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Gupta, NA, Kolachala, VL, Jiang, R, Abramowsky, C, Shenoi, A, Kosters, A, Pavuluri, H, Anania, F, and Kirk, AD. "Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver." AJP: Gastrointestinal and Liver Physiology 307, no. 11 (December 1, 2014): G1088-G1099.

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Mou, D, Espinosa, J, Lo, DJ, and Kirk, AD. "CD28 negative T cells: is their loss our gain?." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 11 (November 2014): 2460-2466. (Review)

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Samy, KP, Martin, BM, Turgeon, NA, and Kirk, AD. "Islet cell xenotransplantation: a serious look toward the clinic." Xenotransplantation 21, no. 3 (May 2014): 221-229.

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Kirk, AD, Guasch, A, Xu, H, Cheeseman, J, Mead, SI, Ghali, A, Mehta, AK, Wu, D, Gebel, H, Bray, R, Horan, J, Kean, LS, Larsen, CP, and Pearson, TC. "Renal Transplantation Using Belatacept Without Maintenance Steroids or Calcineurin Inhibitors." American Journal of Transplantation 14, no. 5 (May 2014): 1142-1151.

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