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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Campus Mail: 3704, Durham, NC 27710
Email: allan.kirk@duke.edu

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants and Awards

Selected Publications

Anderson, D. J., D. J. Lo, F. Leopardi, M. Song, N. A. Turgeon, E. A. Strobert, J. B. Jenkins, et al. “Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection.” Am J Transplant 16, no. 5 (May 2016): 1456–64. https://doi.org/10.1111/ajt.13628.

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Espinosa, J., F. Herr, G. Tharp, S. Bosinger, M. Song, A. B. Farris, R. George, et al. “CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection.” Am J Transplant 16, no. 4 (April 2016): 1102–12. https://doi.org/10.1111/ajt.13613.

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Xu, H., K. P. Samy, A. Guasch, S. I. Mead, A. Ghali, A. Mehta, L. Stempora, and A. D. Kirk. “Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients.” Am J Transplant 16, no. 2 (February 2016): 550–64. https://doi.org/10.1111/ajt.13469.

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Freedman, Barry I., Stephen O. Pastan, Ajay K. Israni, David Schladt, Bruce A. Julian, Michael D. Gautreaux, Vera Hauptfeld, et al. “APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.” Transplantation 100, no. 1 (January 2016): 194–202. https://doi.org/10.1097/TP.0000000000000969.

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Cooper, David K. C., Rita Bottino, Pierre Gianello, Melanie Graham, Wayne J. Hawthorne, Allan D. Kirk, Olle Korsgren, Chung-Gyu Park, and Collin Weber. “First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial.” Xenotransplantation 23, no. 1 (January 2016): 46–52. https://doi.org/10.1111/xen.12226.

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Elder, Robert W., Roshan P. George, Nancy M. McCabe, Fred H. Rodriguez, Wendy M. Book, William T. Mahle, and Allan D. Kirk. “Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?” Pediatr Cardiol 36, no. 7 (October 2015): 1411–16. https://doi.org/10.1007/s00246-015-1174-9.

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Freitas, A. M., K. P. Samy, A. B. Farris, F. V. Leopardi, M. Song, L. Stempora, E. A. Strobert, J. A. Jenkins, A. D. Kirk, and L. C. Cendales. “Studies Introducing Costimulation Blockade for Vascularized Composite Allografts in Nonhuman Primates.” Am J Transplant 15, no. 8 (August 2015): 2240–49. https://doi.org/10.1111/ajt.13379.

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Cendales, L., R. Bray, H. Gebel, L. Brewster, R. Elbein, D. Farthing, M. Song, et al. “Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report.” Am J Transplant 15, no. 8 (August 2015): 2250–55. https://doi.org/10.1111/ajt.13217.

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Mou, Danny, Jaclyn E. Espinosa, Linda Stempora, Neal N. Iwakoshi, and Allan D. Kirk. “Viral-induced CD28 loss evokes costimulation independent alloimmunity.” J Surg Res 196, no. 2 (June 15, 2015): 241–46. https://doi.org/10.1016/j.jss.2015.02.033.

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Beasley, Georgia M., Theodore N. Pappas, and Allan D. Kirk. “Procedure Delegation by Attending Surgeons Performing Concurrent Operations in Academic Medical Centers: Balancing Safety and Efficiency.” Ann Surg 261, no. 6 (June 2015): 1044–45. https://doi.org/10.1097/SLA.0000000000001208.

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Lo, D. J., D. J. Anderson, M. Song, F. Leopardi, A. B. Farris, E. Strobert, S. Chapin, B. Devens, E. Karrer, and A. D. Kirk. “A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation.” Am J Transplant 15, no. 4 (April 2015): 984–92. https://doi.org/10.1111/ajt.13100.

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Gupta, Nitika A., Vasantha L. Kolachala, Rong Jiang, Carlos Abramowsky, Asha Shenoi, Astrid Kosters, Haritha Pavuluri, Frank Anania, and Allan D. Kirk. “Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver.” Am J Physiol Gastrointest Liver Physiol 307, no. 11 (December 1, 2014): G1088–99. https://doi.org/10.1152/ajpgi.00210.2014.

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Samy, Kannan P., Benjamin M. Martin, Nicole A. Turgeon, and Allan D. Kirk. “Islet cell xenotransplantation: a serious look toward the clinic.” Xenotransplantation 21, no. 3 (May 2014): 221–29. https://doi.org/10.1111/xen.12095.

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Kirk, A. D., A. Guasch, H. Xu, J. Cheeseman, S. I. Mead, A. Ghali, A. K. Mehta, et al. “Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.” Am J Transplant 14, no. 5 (May 2014): 1142–51. https://doi.org/10.1111/ajt.12712.

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