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Garnett H. Kelsoe, DSc

James B. Duke Distinguished Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • AssociateProfessor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University , 1979

Selected Grants and Awards

Selected Publications

Kelsoe, Garnett, and Barton F. Haynes. “What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Breaking through Immunity's Glass Ceiling.” Cold Spring Harb Perspect Biol 10, no. 5 (May 1, 2018). https://doi.org/10.1101/cshperspect.a029397.

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Yeh, Chen-Hao, Takuya Nojima, Masayuki Kuraoka, and Garnett Kelsoe. “Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density.” Nat Commun 9, no. 1 (March 2, 2018): 928. https://doi.org/10.1038/s41467-018-03382-x.

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McCarthy, Kevin R., Akiko Watanabe, Masayuki Kuraoka, Khoi T. Do, Charles E. McGee, Gregory D. Sempowski, Thomas B. Kepler, Aaron G. Schmidt, Garnett Kelsoe, and Stephen C. Harrison. “Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.” Immunity 48, no. 1 (January 2018): 174-184.e9. https://doi.org/10.1016/j.immuni.2017.12.009.

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Kuraoka, Masayuki, Pilar B. Snowden, Takuya Nojima, Laurent Verkoczy, Barton F. Haynes, Daisuke Kitamura, and Garnett Kelsoe. “BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance.” Cell Reports 18, no. 7 (February 2017): 1627–35. https://doi.org/10.1016/j.celrep.2017.01.050.

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Abbott, Robert K., Molly Thayer, Jasmine Labuda, Murillo Silva, Phaethon Philbrook, Derek W. Cain, Hidefumi Kojima, et al. “Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.” J Immunol 197, no. 10 (November 15, 2016): 4014–20. https://doi.org/10.4049/jimmunol.1601401.

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Kuraoka, Masayuki, Aaron G. Schmidt, Takuya Nojima, Feng Feng, Akiko Watanabe, Daisuke Kitamura, Stephen C. Harrison, Thomas B. Kepler, and Garnett Kelsoe. “Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.” Immunity 44, no. 3 (March 15, 2016): 542–52. https://doi.org/10.1016/j.immuni.2016.02.010.

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Reynolds, Alexander E., Masayuki Kuraoka, and Garnett Kelsoe. “Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.” J Immunol 194, no. 1 (January 1, 2015): 231–42. https://doi.org/10.4049/jimmunol.1401203.

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Liu, Mengfei, Guang Yang, Kevin Wiehe, Nathan I. Nicely, Nathan A. Vandergrift, Wes Rountree, Mattia Bonsignori, et al. “Polyreactivity and autoreactivity among HIV-1 antibodies.” J Virol 89, no. 1 (January 2015): 784–98. https://doi.org/10.1128/JVI.02378-14.

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Kepler, Thomas B., Hua-Xin Liao, S Munir Alam, Rekha Bhaskarabhatla, Ruijun Zhang, Chandri Yandava, Shelley Stewart, et al. “Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies.” Cell Host Microbe 16, no. 3 (September 10, 2014): 304–13. https://doi.org/10.1016/j.chom.2014.08.006.

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Gao, Feng, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Fangping Cai, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.” Cell 158, no. 3 (July 31, 2014): 481–91. https://doi.org/10.1016/j.cell.2014.06.022.

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Holl, T Matt, Guang Yang, Masayuki Kuraoka, Laurent Verkoczy, S Munir Alam, M Anthony Moody, Barton F. Haynes, and Garnett Kelsoe. “Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.” J Immunol 192, no. 7 (April 1, 2014): 3269–79. https://doi.org/10.4049/jimmunol.1302829.

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Cain, Derek W., Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn, and Garnett Kelsoe. “Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.” J Immunol 191, no. 9 (November 1, 2013): 4665–75. https://doi.org/10.4049/jimmunol.1300581.

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McWilliams, Laurie, Kuei-Ying Su, Xiaoe Liang, Dongmei Liao, Serina Floyd, Joshua Amos, M Anthony Moody, Garnett Kelsoe, and Masayuki Kuraoka. “The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors.” J Leukoc Biol 94, no. 5 (November 2013): 991–1001. https://doi.org/10.1189/jlb.0113048.

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