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Garnett H. Kelsoe, DSc

James B. Duke Professor of Immunology
Campus Mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815
Email: ghkelsoe@duke.edu

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Professor, Microbiology And Immunology, University of Maryland School of Medicine, 1994 - 1998
  • Associate Professor, Microbiology & Immunology, University of Maryland School of Medicine, 1989 - 1994
  • Associate Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1988 - 1989
  • Assistant Professor, Microbiology, University of Texas, Medical Branch at Galveston, 1982 - 1988
  • D.Sc., Harvard University, 1979

Selected Publications

Kelsoe, G. "Heavy-chain receptor editing unbound." Proceedings of the National Academy of Sciences of the United States of America 112, no. 8 (February 17, 2015): 2297-2298.

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Reynolds, AE, Kuraoka, M, and Kelsoe, G. "Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow." Journal of immunology (Baltimore, Md. : 1950) 194, no. 1 (January 2015): 231-242.

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Liu, M, Yang, G, Wiehe, K, Nicely, NI, Vandergrift, NA, Rountree, W, Bonsignori, M, Alam, SM, Gao, J, Haynes, BF, and Kelsoe, G. "Polyreactivity and autoreactivity among HIV-1 antibodies." Journal of virology 89, no. 1 (January 2015): 784-798.

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Kepler, TB, Liao, H-X, Alam, SM, Bhaskarabhatla, R, Zhang, R, Yandava, C, Stewart, S, Anasti, K, Kelsoe, G, Parks, R, Lloyd, KE, Stolarchuk, C, Pritchett, J, Solomon, E, Friberg, E, Morris, L, Karim, SSA, Cohen, MS, Walter, E, Moody, MA, Wu, X, Altae-Tran, HR, Georgiev, IS, Kwong, PD, Boyd, SD, Fire, AZ, Mascola, JR, and Haynes, BF. "Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies." Cell host & microbe 16, no. 3 (September 2014): 304-313.

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Gao, F, Bonsignori, M, Liao, H-X, Kumar, A, Xia, S-M, Lu, X, Cai, F, Hwang, K-K, Song, H, Zhou, T, Lynch, RM, Alam, SM, Moody, MA, Ferrari, G, Berrong, M, Kelsoe, G, Shaw, GM, Hahn, BH, Montefiori, DC, Kamanga, G, Cohen, MS, Hraber, P, Kwong, PD, Korber, BT, Mascola, JR, Kepler, TB, and Haynes, BF. "Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies." Cell 158, no. 3 (July 24, 2014): 481-491.

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Holl, TM, Yang, G, Kuraoka, M, Verkoczy, L, Alam, SM, Moody, MA, Haynes, BF, and Kelsoe, G. "Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes." Journal of immunology (Baltimore, Md. : 1950) 192, no. 7 (April 2014): 3269-3279.

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Cain, DW, O'Koren, EG, Kan, MJ, Womble, M, Sempowski, GD, Hopper, K, Gunn, MD, and Kelsoe, G. "Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages." J Immunol 191, no. 9 (November 1, 2013): 4665-4675.

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McWilliams, L, Su, K-Y, Liang, X, Liao, D, Floyd, S, Amos, J, Moody, MA, Kelsoe, G, and Kuraoka, M. "The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors." J Leukoc Biol 94, no. 5 (November 2013): 991-1001.

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Yang, G, Holl, TM, Liu, Y, Li, Y, Lu, X, Nicely, NI, Kepler, TB, Alam, SM, Liao, H-X, Cain, DW, Spicer, L, VandeBerg, JL, Haynes, BF, and Kelsoe, G. "Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies." J Exp Med 210, no. 2 (February 11, 2013): 241-256.

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Haynes, BF, Kelsoe, G, Harrison, SC, and Kepler, TB. "B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. (Published online)" Nat Biotechnol 30, no. 5 (May 7, 2012): 423-433.

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Verkoczy, L, Chen, Y, Bouton-Verville, H, Zhang, J, Diaz, M, Hutchinson, J, Ouyang, Y-B, Alam, SM, Holl, TM, Hwang, K-K, Kelsoe, G, and Haynes, BF. "Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls." J Immunol 187, no. 7 (October 1, 2011): 3785-3797.

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Kuraoka, M, Holl, TM, Liao, D, Womble, M, Cain, DW, Reynolds, AE, and Kelsoe, G. "Activation-induced cytidine deaminase mediates central tolerance in B cells." Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11560-11565.

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Verkoczy, L, Kelsoe, G, Moody, MA, and Haynes, BF. "Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies." Curr Opin Immunol 23, no. 3 (June 2011): 383-390. (Review)

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Cain, DW, Snowden, PB, Sempowski, GD, and Kelsoe, G. "Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism." PLoS One 6, no. 5 (2011): e19957-.

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Nicely, NI, Dennison, SM, Spicer, L, Scearce, RM, Kelsoe, G, Ueda, Y, Chen, H, Liao, H-X, Alam, SM, and Haynes, BF. "Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region." Nat Struct Mol Biol 17, no. 12 (December 2010): 1492-1494.

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