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Georgia Doris Tomaras, PhD

Professor in Surgery
Campus Mail: Box 103020 DUMC, Durham, NC 27710
Phone: (919) 681-5598
Email: gdt@duke.edu

Research in the Tomaras Laboratory in the Duke Human Vaccine Institute and Departments of Surgery, Immunology, and Molecular Genetics and Microbiology at Duke University Medical Center, focuses on the identification of immune correlates of protection for preventative vaccines and identification of the mechanisms responsible for potent inhibition of human pathogens.  

Education and Training

  • Postdoctoral Fellowship, Center For Aids Research, Department Of Surgery, Duke University, 1998 - 2001
  • Ph.D., SUNY Upstate Medical University, 1998

Selected Grants and Awards

Selected Publications

Fong, Y, Datta, S, Georgiev, IS, Kwong, PD, and Tomaras, GD. "Kernel-based logistic regression model for protein sequence without vectorialization." Biostatistics (Oxford, England) 16, no. 3 (July 2015): 480-492.

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Tomescu, C, Seaton, KE, Smith, P, Taylor, M, Tomaras, GD, Metzger, DS, and Montaner, LJ. "Innate activation of MDC and NK cells in high-risk HIV-1-exposed seronegative IV-drug users who share needles when compared with low-risk nonsharing IV-drug user controls." Journal of acquired immune deficiency syndromes (1999) 68, no. 3 (March 2015): 264-273.

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Bogers, WM, Oostermeijer, H, Mooij, P, Koopman, G, Verschoor, EJ, Davis, D, Ulmer, JB, Brito, LA, Cu, Y, Banerjee, K, Otten, GR, Burke, B, Dey, A, Heeney, JL, Shen, X, Tomaras, GD, Labranche, C, Montefiori, DC, Liao, H-X, Haynes, B, Geall, AJ, and Barnett, SW. "Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion." The Journal of infectious diseases 211, no. 6 (March 2015): 947-955.

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Sacha, CR, Vandergrift, N, Jeffries, TL, McGuire, E, Fouda, GG, Liebl, B, Marshall, DJ, Gurley, TC, Stiegel, L, Whitesides, JF, Friedman, J, Badiabo, A, Foulger, A, Yates, NL, Tomaras, GD, Kepler, TB, Liao, HX, Haynes, BF, Moody, MA, and Permar, SR. "Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women." Mucosal immunology 8, no. 2 (March 2015): 316-326.

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Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Pollara, J, Song, LY, Liebl, BE, Whitaker, K, Shen, X, Vandergrift, NA, Overman, RG, Yates, NL, Moody, MA, Fry, C, Kim, JH, Michael, NL, Robb, M, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Liao, H-X, Haynes, BF, Montefiori, DC, Ferrari, G, Tomaras, GD, and Permar, SR. "Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses." The Journal of infectious diseases 211, no. 4 (February 2015): 508-517.

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Wiehe, K, Easterhoff, D, Luo, K, Nicely, NI, Bradley, T, Jaeger, FH, Dennison, SM, Zhang, R, Lloyd, KE, Stolarchuk, C, Parks, R, Sutherland, LL, Scearce, RM, Morris, L, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Sinangil, F, Phogat, S, Michael, NL, Kim, JH, Kelsoe, G, Montefiori, DC, Tomaras, GD, Bonsignori, M, Santra, S, Kepler, TB, Alam, SM, Moody, MA, Liao, H-X, and Haynes, BF. "Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved." Immunity 41, no. 6 (December 2014): 909-918.

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Bart, P-A, Huang, Y, Karuna, ST, Chappuis, S, Gaillard, J, Kochar, N, Shen, X, Allen, MA, Ding, S, Hural, J, Liao, H-X, Haynes, BF, Graham, BS, Gilbert, PB, McElrath, MJ, Montefiori, DC, Tomaras, GD, Pantaleo, G, and Frahm, N. "HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial." The Journal of clinical investigation 124, no. 11 (November 2014): 4843-4856.

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Frey, SE, Peiperl, L, McElrath, MJ, Kalams, S, Goepfert, PA, Keefer, MC, Baden, LR, Lally, MA, Mayer, K, Blattner, WA, Harro, CD, Hammer, SM, Gorse, GJ, Hural, J, Tomaras, GD, Levy, Y, Gilbert, P, deCamp, A, Russell, ND, Elizaga, M, Allen, M, and Corey, L. "Phase I/II randomized trial of safety and immunogenicity of LIPO-5 alone, ALVAC-HIV (vCP1452) alone, and ALVAC-HIV (vCP1452) prime/LIPO-5 boost in healthy, HIV-1-uninfected adult participants." Clinical and vaccine immunology : CVI 21, no. 11 (November 2014): 1589-1599.

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Stieh, DJ, King, DF, Klein, K, Liu, P, Shen, X, Hwang, KK, Ferrari, G, Montefiori, DC, Haynes, B, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Michael, NL, Robb, ML, Kim, JH, Denny, TN, Tomaras, GD, and Shattock, RJ. "Aggregate complexes of HIV-1 induced by multimeric antibodies." Retrovirology 11 (October 2, 2014): 78-.

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Fouda, G, Pollara, J, McGuire, E, Rountree, W, Overman, G, Tegha, G, Kamwendo, D, Kumwenda, J, Nelson, J, Liao, L, Ellington, S, King, C, Jamieson, D, Van der Horst, C, Kourtis, A, Tomaras, G, Ferrari, G, and Permar, S. "Association of HIV-1 Env Antibody Responses with Postnatal Mother-to-Child Transmission of HIV-1 via Breastfeeding." October 2014.

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Shen, X, Williams, W, Yates, N, Francica, J, Reimann, K, Montefiori, D, McElrath, J, Seder, R, and Tomaras, G. "HIV ENV-SPECIFIC IGG3 RESPONSES ARE DIFFERENTIALLY ELICITED IN NONHUMAN PRIMATE BY ENV VACCINES WITH DIFFERENT ADJUVANTS." October 2014.

Scholars@Duke

Moody, MA, Easterhoff, D, Gurley, TC, Whitesides, JF, Marshall, DJ, Foulger, A, Lloyd, KE, Parks, R, Pollara, J, Duffy, R, Shen, S, Kim, JH, Michael, NL, Robb, ML, O'Connell, RJ, Vasan, S, Excler, JL, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Nitayaphan, S, Sinangil, F, Francis, D, Lee, C, Kepler, TB, Alam, SM, Ferrari, G, Montefiori, DC, Liao, HX, Tomaras, GD, and Haynes, BF. "Induction of Antibodies with Long Variable Heavy Third Complementarity Determining Regions by Repetitive Boosting with AIDSVAX® B/E in RV144 Vaccinees." October 2014.

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Sixsmith, JD, Panas, MW, Lee, S, Gillard, GO, White, K, Lifton, MA, Balachandran, H, Mach, L, Miller, JP, Lavine, C, DeMarco, CT, Tomaras, GD, Gee, C, Porcelli, SA, Larsen, MH, Frothingham, R, Schmitz, JE, Jacobs, WR, Haynes, BF, Letvin, NL, and Korioth-Schmitz, B. "Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques." Clinical and vaccine immunology : CVI 21, no. 10 (October 2014): 1385-1395.

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Liao, LH, Trama, AM, Williams, WB, Moody, MA, Vandergrift, N, Tomaras, GD, Marshall, DJ, Gurley, T, Whitesides, J, Eudailey, J, Foulger, A, Parks, R, Stolarchuk, C, Lloyd, KE, Soderberg, K, Mascola, JR, Koup, R, Corey, L, Nabel, GB, Gilber, P, Morgan, C, Maenza, J, Keefer, M, Hammer, S, Churchyard, G, Montefior, DC, Graham, BS, Baden, LR, Kepler, TB, and Haynes, BF. "Role of Intestinal Microbiota in Shaping the B Cell Repertoire in HIV Infection and Env Vaccination." October 1, 2014.

Scholars@Duke

Li, SS, Gilbert, PB, Tomaras, GD, Kijak, G, Ferrari, G, Thomas, R, Pyo, C-W, Zolla-Pazner, S, Montefiori, D, Liao, H-X, Nabel, G, Pinter, A, Evans, DT, Gottardo, R, Dai, JY, Janes, H, Morris, D, Fong, Y, Edlefsen, PT, Li, F, Frahm, N, Alpert, MD, Prentice, H, Rerks-Ngarm, S, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Robb, ML, O'Connell, RJ, Haynes, BF, Michael, NL, Kim, JH, McElrath, MJ, and Geraghty, DE. "FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial." The Journal of clinical investigation 124, no. 9 (September 2014): 3879-3890.

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