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Russell P. Hall, MD

J. Lamar Callaway Professor of Dermatology, in the School of Medicine
Campus Mail: 4044 Hosp South, Durham, NC 27710
Phone: (919) 684-3110
Email: hall0009@mc.duke.edu

Our laboratory is investigating the pathogenesis of autoimmune blistering skin diseases. Areas of special expertise include immune mediated skin diseases, especially immune mediated primary blistering disorders. These include pathogenesis, diagnosis, and management.
Specifically our laboratory is investigating the role of the mucosal immune response in the pathogenesis of dermatitis herpetiformis (DH) and the role the associated gluten sensitive enteropathy (GSE) plays in the development of this disease. Studies are currently focused on understanding the systemic manifestations of the mucosal immune response to dietary ingestion of wheat proteins in patients with DH. Studies are directed at determining the pattern of cytokine activation and inflammatory cell activation in the gut, skin and circulation. These studies are focused on understanding the manner in which gastrointestinal inflammation leads to the development of skin lesions in patients with DH and will provide new insight into the pathogenesis of the numerous skin diseases associated with inflammatory gastrointestinal disease.
In addition, our laboratory is investigating the pathogenesis of the organ specific auto immune blistering diseases bullous pemphigoid, and pemphigus vulgaris. These studies are directed at understanding auto-antibody epitopes and their relationship to disease activity and the role of B cells in the development and maintaince of auto-antibodies. Clinical trials are ongoing in both pemphigus and bullous pemphigoid that are coupled with mechanistic studies.

Education and Training

  • Dermatology, Johns Hopkins University School of Medicine, 1981 - 1982
  • Dermatology, Clinical Center National Institutes of Health, 1978 - 1981
  • Dermatology, University of Missouri - Columbia School of Medicine, 1977 - 1978
  • Medicine, University of Missouri - Columbia School of Medicine, 1976 - 1977
  • Medicine, St. Louis University, 1975 - 1976
  • M.D., University of Missouri at Columbia, 1975
  • B.A., Westminster College, 1971

Selected Publications

Suarez, EC, Boyle, SH, Lewis, JG, Hall, RP, and Young, KH. "Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator." Brain Behav Immun 20, no. 4 (July 2006): 331-338.

Full Text

Hall, RP, Takeuchi, F, Benbenisty, KM, and Streilein, RD. "Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha." J Invest Dermatol 126, no. 6 (June 2006): 1331-1337.

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Kong, HH, Prose, NS, Ware, RE, and Hall, RP. "Successful treatment of refractory childhood pemphgus vulgaris with anti-CD20 monoclonal antibody (rituximab)." Pediatr Dermatol 22, no. 5 (September 2005): 461-464.

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Whited, JD, Hall, RP, Foy, ME, Marbrey, LE, Grambow, SC, Dudley, TK, Datta, SK, Simel, DL, and Oddone, EZ. "Patient and clinician satisfaction with a store-and-forward teledermatology consult system." Telemedicine journal and e-health : the official journal of the American Telemedicine Association 10, no. 4 (2004): 422-431. (Academic Article)

Scholars@Duke

Takeuchi, F, Sterilein, RD, and Hall, RP. "Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma." Exp Dermatol 12, no. 6 (December 2003): 777-783.

Scholars@Duke

Smith, AD, Streilein, RD, and Hall, RP. "Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis." Br J Dermatol 147, no. 6 (December 2002): 1109-1117.

Scholars@Duke

Szabolcs, P, Reese, M, Yancey, KB, Hall, RP, and Kurtzberg, J. "Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease." Bone Marrow Transplant 30, no. 5 (September 2002): 327-329.

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Hall, RP, Smith, AD, and Streilein, RD. "Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy." Dig Dis Sci 45, no. 10 (October 2000): 2036-2043.

Scholars@Duke

Hall, RP, Owen, S, Smith, A, Keough, M, Bagheri, B, Church, P, and Streilein, R. "TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy." Exp Dermatol 9, no. 4 (August 2000): 275-282.

Scholars@Duke

Roh, JY, Yee, C, Lazarova, Z, Hall, RP, and Yancey, KB. "The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis." Br J Dermatol 143, no. 1 (July 2000): 104-111.

Scholars@Duke

Smith, AD, Bagheri, B, Streilein, RD, and Hall, RP. "Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy." Dig Dis Sci 44, no. 10 (October 1999): 2124-2132.

Scholars@Duke

Rico, MJ, Benning, C, Weingart, ES, Streilein, RD, and Hall, RP. "Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris." Br J Dermatol 140, no. 6 (June 1999): 1079-1086.

Scholars@Duke

Ishii, K, Amagai, M, Hall, RP, Hashimoto, T, Takayanagi, A, Gamou, S, Shimizu, N, and Nishikawa, T. "Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins." J Immunol 159, no. 4 (August 15, 1997): 2010-2017.

Scholars@Duke

Rico, MJ, Hashimototo, T, Watanabe, K, Hall, RP, Clark, RB, and Nishikawa, T. "Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1." J Dermatol Sci 12, no. 3 (September 1996): 238-245.

Scholars@Duke