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Russell P. Hall, MD

J. Lamar Callaway Distinguished Professor of Dermatology, in the School of Medicine
Campus Mail: 4044 Hosp South, Durham, NC 27710
Phone: (919) 684-3110
Email: hall0009@mc.duke.edu

Our laboratory is investigating the pathogenesis of autoimmune blistering skin diseases. Areas of special expertise include immune mediated skin diseases, especially immune mediated primary blistering disorders. These include pathogenesis, diagnosis, and management.
Specifically our laboratory is investigating the role of the mucosal immune response in the pathogenesis of dermatitis herpetiformis (DH) and the role the associated gluten sensitive enteropathy (GSE) plays in the development of this disease. Studies are currently focused on understanding the systemic manifestations of the mucosal immune response to dietary ingestion of wheat proteins in patients with DH. Studies are directed at determining the pattern of cytokine activation and inflammatory cell activation in the gut, skin and circulation. These studies are focused on understanding the manner in which gastrointestinal inflammation leads to the development of skin lesions in patients with DH and will provide new insight into the pathogenesis of the numerous skin diseases associated with inflammatory gastrointestinal disease.
In addition, our laboratory is investigating the pathogenesis of the organ specific auto immune blistering diseases bullous pemphigoid, and pemphigus vulgaris. These studies are directed at understanding auto-antibody epitopes and their relationship to disease activity and the role of B cells in the development and maintaince of auto-antibodies. Clinical trials are ongoing in both pemphigus and bullous pemphigoid that are coupled with mechanistic studies.

Education and Training

  • Dermatology, Johns Hopkins University School of Medicine, 1981 - 1982
  • Dermatology, Clinical Center National Institutes of Health, 1978 - 1981
  • Dermatology, University of Missouri, Columbia School of Medicine, 1977 - 1978
  • Medicine, University of Missouri, Columbia School of Medicine, 1976 - 1977
  • Medicine, Saint Louis University, 1975 - 1976
  • M.D., University of Missouri, Columbia, 1975
  • B.A., Westminster College, 1971

Selected Publications

Suarez, Edward C., Stephen H. Boyle, James G. Lewis, Russell P. Hall, and Kenneth H. Young. “Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator.” Brain Behav Immun 20, no. 4 (July 2006): 331–38. https://doi.org/10.1016/j.bbi.2005.09.005.

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Hall, Russell P., Fumiko Takeuchi, Keith M. Benbenisty, and Robert D. Streilein. “Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha.” J Invest Dermatol 126, no. 6 (June 2006): 1331–37. https://doi.org/10.1038/sj.jid.5700277.

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Kong, Heidi H., Neil S. Prose, Russell E. Ware, and Russell P. Hall. “Successful treatment of refractory childhood pemphgus vulgaris with anti-CD20 monoclonal antibody (rituximab).” Pediatr Dermatol 22, no. 5 (September 2005): 461–64. https://doi.org/10.1111/j.1525-1470.2005.00118.x.

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Whited, John D., Russell P. Hall, Marjorie E. Foy, Laurie E. Marbrey, Steven C. Grambow, Tara K. Dudley, Santanu K. Datta, David L. Simel, and Eugene Z. Oddone. “Patient and clinician satisfaction with a store-and-forward teledermatology consult system.” Telemed J E Health 10, no. 4 (2004): 422–31. https://doi.org/10.1089/tmj.2004.10.422.

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Szabolcs, P., M. Reese, K. B. Yancey, R. P. Hall, and J. Kurtzberg. “Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease.” Bone Marrow Transplant 30, no. 5 (September 2002): 327–29. https://doi.org/10.1038/sj.bmt.1703654.

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Hall, R. P., A. D. Smith, and R. D. Streilein. “Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy.” Dig Dis Sci 45, no. 10 (October 2000): 2036–43. https://doi.org/10.1023/a:1005512513007.

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Hall, R. P., S. Owen, A. Smith, M. Keough, B. Bagheri, P. Church, and R. Streilein. “TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy.” Exp Dermatol 9, no. 4 (August 2000): 275–82. https://doi.org/10.1034/j.1600-0625.2000.009004275.x.

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Roh, J. Y., C. Yee, Z. Lazarova, R. P. Hall, and K. B. Yancey. “The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis.” Br J Dermatol 143, no. 1 (July 2000): 104–11. https://doi.org/10.1046/j.1365-2133.2000.03598.x.

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Smith, A. D., B. Bagheri, R. D. Streilein, and R. P. Hall. “Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy.” Dig Dis Sci 44, no. 10 (October 1999): 2124–32. https://doi.org/10.1023/a:1026699108147.

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Ishii, K., M. Amagai, R. P. Hall, T. Hashimoto, A. Takayanagi, S. Gamou, N. Shimizu, and T. Nishikawa. “Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins.” J Immunol 159, no. 4 (August 15, 1997): 2010–17.

Scholars@Duke

Rico, M. J., T. Hashimototo, K. Watanabe, R. P. Hall, R. B. Clark, and T. Nishikawa. “Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1.” J Dermatol Sci 12, no. 3 (September 1996): 238–45. https://doi.org/10.1016/0923-1811(95)00479-3.

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