Sacha, CR, Vandergrift, N, Jeffries, TL, McGuire, E, Fouda, GG, Liebl, B, Marshall, DJ, Gurley, TC, Stiegel, L, Whitesides, JF, Friedman, J, Badiabo, A, Foulger, A, Yates, NL, Tomaras, GD, Kepler, TB, Liao, HX, Haynes, BF, Moody, MA, and Permar, SR. "Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women." Mucosal immunology 8, no. 2 (March 2015): 316-326.
Sallie Robey Permar, MD, PhD
Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.
Education and Training
- Fellowship In Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
- Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
- Ph.D., Johns Hopkins University, 2004
- M.D., Harvard Medical School, 2004
Selected Grants and Awards
Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Pollara, J, Song, LY, Liebl, BE, Whitaker, K, Shen, X, Vandergrift, NA, Overman, RG, Yates, NL, Moody, MA, Fry, C, Kim, JH, Michael, NL, Robb, M, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Liao, H-X, Haynes, BF, Montefiori, DC, Ferrari, G, Tomaras, GD, and Permar, SR. "Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses." The Journal of infectious diseases 211, no. 4 (February 2015): 508-517.
Kaur, A, Barry, P, Bialas, K, Tran, D, Varner, V, Kunz, E, Amos, J, Kirchherr, J, Kattenhorn, L, Wachtman, L, Tanaka, T, and Permar, SR. "SUCCESSFUL DEVELOPMENT OF A NONHUMAN PRIMATE MODEL OF CONGENITAL CYTOMEGALOVIRUS TRANSMISSION." JOURNAL OF MEDICAL PRIMATOLOGY 43, no. 5 (October 2014): 426-426.
Chahroudi, A, Cartwright, E, Carnathan, DG, Lee, ST, Lawson, B, Carnathan, PM, Hashempoor, T, Murphy, MK, Meeker, T, Ehnert, S, Souder, C, Else, JG, Cohen, J, Vanderford, TH, Permar, SR, Derdeyn, CA, Villinger, F, and Silvestri, G. "TARGET CELL AVAILABILITY, RATHER THAN BREAST MILK SPECIFIC FACTORS, DICTATES MOTHER-TO-INFANT TRANSMISSION OF SIV." JOURNAL OF MEDICAL PRIMATOLOGY 43, no. 5 (October 2014): 385-385.
Fouda, GG, and Permar, SR. "Immune-based interventions to prevent postnatal HIV-1 transmission." Trends in microbiology 22, no. 8 (August 2014): 425-427.
Madani, N, Princiotto, AM, Schön, A, LaLonde, J, Feng, Y, Freire, E, Park, J, Courter, JR, Jones, DM, Robinson, J, Liao, H-X, Moody, MA, Permar, S, Haynes, B, Smith, AB, Wyatt, R, and Sodroski, J. "CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies." Journal of virology 88, no. 12 (June 2014): 6542-6555.
Permar, SR, and Staats, HF. "Which comes first: the antigen or the adjuvant?." The Journal of clinical investigation 124, no. 6 (June 2014): 2364-2365.
Chahroudi, A, Cartwright, E, Lee, ST, Mavigner, M, Carnathan, DG, Lawson, B, Carnathan, PM, Hashempoor, T, Murphy, MK, Meeker, T, Ehnert, S, Souder, C, Else, JG, Cohen, J, Collman, RG, Vanderford, TH, Permar, SR, Derdeyn, CA, Villinger, F, and Silvestri, G. "Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques." PLoS pathogens 10, no. 3 (March 6, 2014): e1003958-.
Meyer, SA, Westreich, DJ, Patel, E, Ehlinger, EP, Kalilani, L, Lovingood, RV, Denny, TN, Swamy, GK, and Permar, SR. "Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers." Infectious Diseases in Obstetrics and Gynecology 2014 (January 2014): 989721-.
Fouda, GG, Jaeger, FH, Amos, JD, Ho, C, Kunz, EL, Anasti, K, Stamper, LW, Liebl, BE, Barbas, KH, Ohashi, T, Moseley, MA, Liao, H-X, Erickson, HP, Alam, SM, and Permar, SR. "Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk." Proc Natl Acad Sci U S A 110, no. 45 (November 5, 2013): 18220-18225.
Kunz, E, Fouda, G, Ho, C, Amos, J, Colvin, L, Montefiori, D, Martelli, A, Allen, A, Aramand, L, Marshall, DJ, Letvin, NL, Staats, H, Pickup, D, Barnett, SC, Moody, MA, Haynes, BF, Liao, H, and Permar, SR. "Combined Mucosal and Systemic C.1086 Envelope Immunization of Lactating Monkeys Induces Potent IgA and Functional IgG Antibody Responses in Milk." November 1, 2013.
Sacha, CR, Vandergrift, N, Marshall, DJ, Gurley, TC, Stiegel, L, Whitesides, JF, Friedman, J, Fouda, GG, Liebl, B, McGuire, E, Foulger, A, Kepler, TB, Liao, H, Haynes, BF, Moody, MA, and Permar, SR. "Distinct VH Gene Usage and HIV Envelope Specificity of Colostrum and Peripheral B Cell Monoclonal Antibodies of HIV-Infected, Lactating African Women." November 1, 2013.
Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Liebl, BE, Liao, H, Haynes, BF, Overman, R, Yates, NL, Tomaras, GD, and Permar, SR. "HIV-1 gp120 Vaccination Elicits a Robust and Durable Anti-V1/V2 IgG Response and Yet No HIV-1 Env-Specific IgA Response in HIV-Exposed Infants." November 1, 2013.
Amos, JD, Wilks, AB, Fouda, GG, Smith, SD, Colvin, L, Mahlokozera, T, Ho, C, Beck, K, Overman, RG, DeMarco, CT, Hodge, TL, LaBranche, CC, Montefiori, DC, Denny, TN, Liao, H-X, Tomaras, GD, Moody, MA, and Permar, SR. "Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys." J Virol 87, no. 20 (October 2013): 11121-11134.
Ho, C, Wu, S, Amos, JD, Colvin, L, Smith, SD, Wilks, AB, Demarco, CT, Brinkley, C, Denny, TN, Schmitz, JE, Rodrigo, AG, and Permar, SR. "Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys." J Virol 87, no. 20 (October 2013): 11292-11299.